摘要
目的探讨甲基强的松龙(MP)在肾移植术后巨细胞病毒(CMV)重症肺炎患者治疗中的作用。方法分析我院收治的95例肾移植术后CMV重症肺炎患者的临床资料,其中50例加用MP治疗(MP组),45例未加用MP治疗(对照组),比较两组患者的临床疗效。结果MP组体温恢复正常时间、呼吸窘迫症状持续时间、机械通气时间及ICU入住时间明显缩短(P<0.001),机械通气例次明显减少(P<0.01),氧合情况明显改善(P<0.001)。MP组治疗有效率为86%,明显好于对照组(60%,P<0.01)。MP组死亡率为12%,对照组为37.8%,两组差异有统计学意义(P<0.01)。结论MP治疗能够缩短CMV重症肺炎的病程,提高CMV肺炎患者治疗有效率,降低患者死亡率。
Objective To investigate the therapeutic action of methylprednisolone （MP） in cytomegalovirus （ CMV ） severe pneumonia following kidney transplantation. Methods The therapy for 45 patients of control group included the elimination of immunosuppressive agents, the use of antiviral drug, measures to prevent and cure other bacterial and fungal infections, oxygen inhalation or mechanical ventilation. Besides the above therapies, MP was injected to 50 patients of MP group. The clinical data of all the patients were analyzed. Results The time of fever, dyspnea, stay in ICU and mechanical ventilation in MP group was shorter than that of control group （ P 〈0.001 ）. There were significant differences between the two groups in the probability of using mechanical ventilation and the mortality （ P 〈 0.01 ）. The total effective rate in MP group and control group were 86% and 60%, respectively, there was significant difference between two groups （ P 〈 0.01 ）. Conclusions The treatments with MP are effective and can decrease the mortality of CMV pneumonia following kidney transplantation.
出处
《中国急救医学》
CAS
CSCD
北大核心
2008年第11期982-983,共2页
Chinese Journal of Critical Care Medicine
关键词
肾移植
肺炎
巨细胞病毒
甲基强的松龙
治疗
Kidney transplantation
Pneumonia
Cytomegalovirus（ CMV}
Methylprednisolone （MP）
Treatment
