摘要
目的：评价血清肿瘤标志物CA19-9在胰腺癌患者中的临床应用价值。方法：运用回顾性方法统计分析2001.1~2004.1华西医院和四川省人民医院经手术治疗的132例胰腺癌患者临床资料以及血清CA19-9检测结果。结果：132例胰腺癌患者血清CA19-9平均值589±172.21、血清阳性率87.12%,较正常健康人明显增高。胰腺癌患者血清CA19-9值〉200 u/mL组其远处转移率为67.03%（61/91）,血管受累率为55.0%（50/91）,血清CA19-9值≤200 u/mL组其远处转移率为43.09%（18/41）,血管受累率为37.08%（15/41）,统计结果两组无显著性差异。血清CA19-9值〉200 u/mL组其手术不可切除率为81.32%（74/91）,血清CA19-9值≤200 u/mL组其手术不可切除率为70.73%（29/41）,统计无显著性差异。肿瘤位于胰头部血清CA19-9阳性率为88.0%（53/60）,其平均值为481.71±186.28;肿瘤位于体尾部血清CA19-9阳性率为81.0%（58/72）,其平均值为697.87±313.30,两组统计无显著性差异。结论：胰腺癌血清CA19-9检测对胰腺癌的诊断有价值;胰腺癌患者血清CA19-9值对判断肿瘤有无远处转移、血管受累、手术可否切除在本组未显示有价值,可收集更多病例,有待进一步研究确定;肿瘤部位对血清CA19-9值影响不大。
Objective：To evaluate serum tumor marker carbobydrate antigen 19-9（CA19-9）for the diagnosis and prognosis of pancreatic cancer.Methods：Serum CA19-9 levels were determined gerially electrochemilu minescene in 132 patients with pancreatic cancer coming from West China Hospital and Sichuan province people＇s hospital from jan 2001 to jan 2004.Routine preoperative examinations in all patients consist of ultrasonography,CT-scan and MRI of the abdomen;clinical courses with respect to the pathological data,surgical procedures employed and the prognosis of these patients were evaluate prospectively.Results：Serum CA19-9 level of 589±502.21 and the positive rate 87.12% in 132 patients with pancreatic cancer were significantly higher than that of healthy people.With higher-serum CA19-9（CA19-9〉200 u/mL）level group for the metastasis rate of pancreatic carcinoma and operation resection rate were no significant relation with the lower-serum（CA19-9≤200 u/mL）CA19-9 level group.There were no significant relations between the serum CA19-9 level and other item such as the age,sex,smoking history of the patients,differentiation and location of the tumor.The serum CA19-9 level had significant relations with the stage,size and histological classification of tumor.Conclusion：Serum CA19-9 may be of useful tumor maker for diagnosis of pancreatic carcinoma,prediction of the prognosis of the patients after resection.The serum CA19-9 is unablel for guiding the surgical operation and were be influenced by the stage,size and histological classification of tumor.
出处
《华西医学》
CAS
2008年第4期710-712,共3页
West China Medical Journal
