摘要
目的:观察连续性静脉-静脉血液滤过(continuous venovenous hemofiltration,CVVH)治疗重症急性胰腺炎(severe acute pancreatitis,SAP)的疗效。方法:21例SAP患者在传统治疗方法的基础上加用CVVH治疗。观察治疗前、后临床症状改善情况、急性生理学及慢性健康状况评价Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分、生化指标、动脉血气分析等变化。结果:经过CVVH治疗后,患者临床症状改善明显,APACHEⅡ评分下降明显,血清总胆红素(TP)、丙氨酸氨基转移酶(ALT)、血淀粉酶(AMS)、血钾(K)、血尿素氮(BUN)、血清肌酐(Scr)亦明显下降(TB、AST、AMS、K:P<0.05;BUN、Scr:P<0.01),酸中毒及低氧血症得到纠正(HCO-3:P<0.05;PaO2:P<0.01)。21例患者中存活18例(存活率为85.7%),死亡3例(病死率为14.3%),疗效明显。结论:CVVH治疗SAP有明显的效果,能有效改善患者病情,降低病死率。
Objective：To observe the effect of continuous venovenous hemofiltration（CVVH）on the treatment of severe acute pancreatitis（SAP）.Methods：Twenty-one SAP patients underwent CVVH combined by traditional therapy.Their general conditions,liver and kidney functions,arterial blood gas analysis,APACHE Ⅱ acute physiology and chronic health evaluation Ⅱ,APACHEⅡ）score were observed.Results：After CVVH,the clinical symptoms,the APACHE Ⅱcore decreased significantly（P〈0.01）,the level of serum total bilirubin（TB）,alanine aminotransferase（ALT）,amylase（AMS）,serum potassium（K）,blood urea nitrogen（BUN）,and serum creatinine（Scr）notably decreased（TB、ALT、AMS、K：P〈0.05;BUN、Scr：P〈0.01）.Acidosis and hypoxemia were corrected（HCO-3：P〈0.05;PaO2：P〈0.01）.Eighteen patients survived（the survival rate was 85.7%）,3 patients died（the case fatality rate was 14.3%）.The therapeutic effect was excellent.Conclusion：CVVH is effective in treatment of SAP with less case fatality rate and improving patient＇s condition.
出处
《华西医学》
CAS
2008年第2期288-289,共2页
West China Medical Journal
