摘要
通过酶联免疫吸附法测定10名正常人和48名Ⅱ型糖尿病患者血浆β-血小板球蛋白（βTG）和血小板第四因子（PF4_）的水平，来观察和探讨糖尿病患者体内血小板活性状态，以及与糖尿病激血管病变发病机理的关系。研究发现糖尿病患者血浆βTG水平显著高于正常人（P＜0.01），而血浆PF_4水平在糖尿病患者和正常人中无显著差异（P＞0.05），伴或不伴视网膜病变的糖尿病组间血浆βTG、PF_4水平也无显著差异（P值分别＞0．5、＞0．05）。糖尿病患者血浆β水平与空腹血糖浓度之间呈正相关（r=+0.48,P＜0.05）。提示糖尿病患者体内血小板活性升高，可能是由精代谢紊乱所致；是糖尿病做血管病变发生的原因而并非结果。
In order to investigate the platelet activation of diabetics and the relationship with thepathogenesis of microangiopathy in diabetics, plasma levels of β -thromboglobulin (β TG) and plateletfactor 4 (PF_4) in 10 normal controls and 48 NIDDM patients were studied in the present study using theenzyme linked immunosorbent assay (ELISA). We found plasma β TG level was significantly increased inpatients with NIDDM as compared with tbe normal controls (P＜0. 01). However there was no significantdifference in the concentration of PF_4 levels of the NIDDM patients with or without retinopathy (P＞0. 5 and P．＞0. 05, respectively). In the patients with NIDDM, there was a strong correlation betweenplasma β TG and fastintg glucose (r=0. 48. P＜0. 05). These results suggested platelet activityincreased in vivo in patients with diabetes melliitus. The platelet hyperreactivity might be causedby disturbed glucose, and might be a cause of microangiopatby in diabetics.
出处
《镇江医学院学报》
1997年第2期144-145,147,共3页
Journal of Zhenjiang Medical College
