摘要
目的探讨深部真菌感染发病的易患因素、临床特征、诊断、治疗和预防措施。方法应用回顾性调查的方法对47例深部真菌感染患者进行分析。结果47例患者中,念珠菌感染率最高占40.4%(19/47),其次是曲霉菌占31.9%(15/47)。89.4%(42/47)的患者有基础疾病,其中以慢性阻塞性肺疾病(COPD),慢性肾病为多见。原发性深部真菌感染有所增加。广谱抗生素、激素和免疫抑制剂的长时间应用仍是高危因素。深部真菌感染的临床表现无特异性,早期诊断仍困难。结论合理使用抗菌药物及糖皮质激素类药物是预防深部真菌感染的重要措施。重视患者深部组织标本采集对早期诊断十分重要,及时的抗真菌治疗是预后良好的关键。
Objective To investigate the clinical feature ,predisposing risk factors ,diagnosis, therapy and prevention of deep fungal infection. Method 47 cases with deep fungal infection were retrospectively analyzed. Results Among 47 patients, Candida infection rate was as high as 40.4% （19/47）,next was Aspergillus31.9% （15/47）.Various underlying diseases were identified in 89.4% of the 47 eases.Chronic obstructive pulmonary disease （COPD）and chronic kidney diseases were the major predisposing diseases. Primary deep fungal infection is increasing recently. long term use of broad spectrum antibiotic, glucocorticoid and immunosnppressant are still the predisposing risk factors of deep fungal disease. The clinical feature of deep fungal infection has no specific characteristics and the early diagnosis of it is still of some difficulties Conclusion Reasonable useding of antibiotic and glucocorticoid are very important measures to prevent deep fungal infection. Emphasis on the collection of deep tissue specimen is very important for early diagnose and the key point for good recoverment is prompt anti fungal treatment.
关键词
真菌感染
深部
临床分析
fungal infection
Deep
Clinical analysis
