摘要
目的探讨万拉法新联合认知疗法治疗抑郁症的临床疗效。方法将50例抑郁症患者随机分为治疗组和对照组,每组各25例。两组均口服万拉法新治疗,治疗组联合认知疗法,2次/周。治疗8周,再12个月随访。于治疗前及治疗2周、4周、8周末采用汉密顿抑郁量表(HAMD),汉密尔顿焦虑量表(HAMA)及副反应量表(TESS)评定临床疗效和不良反应。12个月随访依据临床疗效总评量表(CGI-SI)评定复发率。结果在治疗后4,8周末,治疗组痊愈率显著高于对照组(P<0.05);两组在治疗2周后HAMD、HAMA评分均较治疗前显著下降(P<0.01),两组间HAMD、HAMA评分在第4周后,治疗组显著低于对照组(P<0.05或P<0.01);治疗1年末随访两组复发率治疗组显著低于对照组(P<0.05)。结论万拉法新配合认知疗法治疗抑郁症郁症效果优于单用万拉法新。
Objective To explore the efficacy and safety of venlafaxine combined with cognitive therapy （CT） in the treatment of depression. Methods 50 patients with depression were randomly divided into the treatment group（n=25 ）treated with combination of venlafaxine and CT and the control group （n=25） with venlafaxine only, twice/week,observed for 8 weeks, and followed up since the end of the 12th month. Efficacies were assessed with the Hamilton Depression Scale（HAMD）, Hamilton anxiety scale（HAMA） and adverse reactions with the Treatment Emergent Symptom Scale （TESS） before treatment and at the ends of the 2nd, 4th and 8th week. Relase rate was assessed with the Clinical Global Impression（CGI-SI） at the end of the 12 month follow-up. Results After 4 and 8 weeks, the curmive rate and effective rate the treatment group were significantly higher than those in the control group. The scores of HAMD and HAMA in the treatment group were significantly lower than those in the control group after 4 weeks. The scores were sign ificantly lower in two groups after 2 weeks of treatment. The incidence of adverse efect and the scores of TESS had no significant difference between the two groups. At the end of 12 month follow-up,relase rate was significantly higher in the control group than in the treatment group P〈0.05 ）.Conclusions Venlafaxine plus cognitive therapy is superior to venlafaxine alone in treatment of depression.
关键词
万拉法新
认知疗法
抑郁症
Venlafaxine
Cognitive therapy
Depression
