摘要
目的了解住院病人常见细菌的菌群分布及耐药特征,为临床感染治疗提供参考依据。方法采用MicroScanAuto-Scan-40半自动微生物鉴定仪和药敏系统及配套进行菌株鉴定与药物敏感性测定,并检测ESBLs。结果2007年10—12月我院临床分离614株细菌中革兰阴性杆菌524(85.3%),革兰阳性球菌90株(14.7%)。革兰阴性杆菌中以大肠埃希菌占多数(152株),其余依次为肺炎克雷伯菌(100株)、鲍曼不动杆菌(80株)、铜绿假单胞菌(79株)。金葡菌(SA)和凝固酶阴性葡萄球菌(CNS)中甲氧西林耐药株(MRSA和MRCNS)各占30.3%和35.3%,未发现耐万古霉素的葡萄球菌和肠球菌;大肠埃希菌和克雷伯菌属产ESBLs的发生率为62.5%和32.0%,革兰阴性杆菌对大多数抗菌药物(除了亚胺培南)耐药率高。结论我院革兰阴性杆菌及革兰阳性球菌耐药性强且多重耐药,应合理应用抗生素并严密监控新的耐药菌的产生。
Objective To investigate the distribution and antibiotic resistance of clinical bacteria isolated from inpatients in our hospital. Methods Bacterial identification and antibiotic susceptibility testing were carried out using MicroScanAutoScan 40 system. ESBLs production was also determined. Results A total of 614 clinical isolates were analyzed, including 90 strains of grampositive cocci and 524 strains of gram-negative bacilli. The prevalence of methiciliin-resistant S. aureus and methicillin-resistant coagulase negative Staphylococcus was 30.3% and 35.3% respectively. No vancomycin-resistant Staphylococcus or Enterococcus strain was identified. ESBLs producing strains accounted for 62.5 % of E. coil and 32 % of Klebsiella. The gram negative bacilli strains were highly resistant to antimicrobial agents （except imipenem）. Conclusions It is important to prescribe antibiotics rationally and monitor the antimicrobial resistance of clinical pathogens.
出处
《中国感染与化疗杂志》
CAS
2008年第6期456-458,共3页
Chinese Journal of Infection and Chemotherapy
关键词
细菌
抗菌药物
耐药性
Bacterium
Antibacterial agent
Drug resistance
