摘要
目的探讨儿科头孢曲松合并用药不良反应发生情况,为临床合理用药提供参考。方法对2004—2007年江苏省药品不良反应监测中心数据库中儿科头孢曲松合并用药不良反应病例报告进行分类统计。结果217例合并用药不良反应病例中,排名前3位的药品种类分别是调节水电解质及酸碱平衡药物(30.88%)、抗病毒类药物(20.74%)、中药注射剂(18.89%);排名前3位的伍用药品分别是利巴韦林(21.05%)、氯化钠(20.53%)、地塞米松(16.84%)。8例严重不良反应病例中的3例死亡,分别为三联或四联用药。结论临床应重视儿科头孢曲松的联合用药,警惕可能因不合理的联合用药诱发严重不良反应。
Objective To investigate the cause and influencing factor of adverse drug reaction （ADR） of cefatriaxone in combination with other drugs in department of pediatrics, and to provide reference for the clinical drug administration. Methods A retrospective research of case reports on adverse drug reactions （ADR） caused by cefatriaxone in combination with other drugs from 2004 to 2007 in the database of Center for ADR Monitoring of Jiangsu was performed for categorization and statistical analysis. Results Of the total 217 ADR reports, medication adjusting water, the electrolyte and the acid - base equilibrium （ 30.88% ）, antiviral drugs （ 20.74% ） and traditional Chinese drug injections （18.89%） are the top 3 drug types, and the top 3 drugs were ribavirin （21.05%）, sodium chloride （20.53%） and dexamethasone （ 16.84% ）. 8 cases were serious ADRs in 217 reports, in which there were 3 deaths, caused by triple or quadruple medication respectively. Conclusion In clinical administration of cefatriaxone in pediatrics, precautions should be taken to prevent the potential risks of severe adverse reactions induced by inappropriate combination with other drugs.
出处
《徐州医学院学报》
CAS
2008年第11期764-767,共4页
Acta Academiae Medicinae Xuzhou
关键词
头孢曲松
联合用药
不良反应
儿童
cefatriaxone
combined medication
adverse drug reaction
child
