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SIRT1在糖脂代谢中的作用

Effects of SIRT1 on glucolipid metabolism
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摘要 SIRT1是一种NAD^＋依赖的组蛋白脱乙酰基蛋白酶，参与体内众多蛋白酶和转录因子的活性调节。在哺乳动物中，SIRT1促进脂肪动员、脂肪酸氧化、葡萄糖产生和胰岛素分泌。SIRT1激动剂可明显改善机体的胰岛素敏感性，降低血浆葡萄糖水平。因此，SIRT1激动剂的使用将可能成为2型糖尿病的新的治疗途径。 SIRT1, a NAD^＋ -dependent deacetylase, regulates activity of many proteases and transcription factors in vivo. In mammals, SIRT1 promotes fat mobilization, fatty acid oxidation, glucose production, and insulin secretion. Some small molecule activators of SIRT1 improve insulin sensitivity and reduce plasma glucose significantly. Accordingly, SIRTI activation is a promising new therapeutic approach for treating type 2 diabetes.
作者 邓向群 成金罗
机构地区 南京医科大学附属常州第二人民医院内分泌科
出处 《国际内分泌代谢杂志》 2008年第6期413-415,共3页 International Journal of Endocrinology and Metabolism
关键词 SIRT1 糖代谢 脂代谢 SIRT1 Glycometabolism Lipid metabolism
分类号 R587.1 [医药卫生—内分泌] R363 [医药卫生—病理学]
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参考文献21

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国际内分泌代谢杂志
2008年 第6期

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