摘要
肾素-血管紧张素系统是体内重要的内分泌系统之一，通常认为其功能主要是调节血压和保持水电解质平衡。但近年的研究证实该系统还参与学习、记忆等认知功能的调节，并在糖尿病脑病的发病过程中发挥重要作用。例如：血管紧张素（Ang）Ⅱ可以抑制乙酰胆碱的释放、抑制长时程增强（LTP）的诱导、干扰胰岛素的信号转导、激活体内的氧化应激以及减少中枢的血供；AngⅣ可以促进乙酰胆碱的释放，易化LTP；Ang-（1-7）可以易化LTP，还能改善中枢血流。这些发现为糖尿病脑病的防治提供了新思路。
Renin-angiotensin system（RAS） is an important endocrine system in the body. Classical, well-defined actions of RAS in the body is the regulation of blood pressure and the balance of water and electrolyte. However, RAS has additionally been implicated in some cognitive functions, such as learning and memory. Furthermore, RAS plays an important role in the pathogenesis of diabetic encephalopathy. For example, Ang Ⅱ inhibits acetylcholine release and long-term potentiation （ LTP）, impairs insulin signaling, activates oxidative stress and reduces cerebral blood flow;Ang Ⅳ can enhance LTP and acetylcholine release; Ang- （ 1-7 ） enhances LTP and increases the blood flow of brain. These findings bring us new hope for the prevention and treatment of diabetic encephalopathy.
出处
《国际内分泌代谢杂志》
2008年第6期384-386,423,共4页
International Journal of Endocrinology and Metabolism
基金
重庆市卫生局医学科研项目（2008-2-79）
