摘要
为了观察卡托普利注射液治疗高血压危象的疗效,将46例患者分为两组进行临床对照试验。治疗组29例,给予卡托普利注射液10mg静滴;对照组17例,给予硝普钠注射液25mg静滴,均为一次性给药比较疗效,两组有效率分别为93.1％、94.1％(治疗前后比较均P<0.01,两组间比较P>0.05),起效时间均为10～40分钟,维持时间对照组仅数分钟,治疗组2h左右(P<0.01)。结果表明:卡托普利注射液降血压作用显著,起效快,维持时间较长、副作用少,疗效确切,安全可靠。
To observe the effect of captopril injectio on hypertensive crisis, 46 patients were divided into 2 groups for clinical control study. The treatment had 29 patients, who were given 10 mg captopril injectio by intravenous drip and control group had 17 subjects who received 25 mg sodium nitroprusside given by intravenous drip. Comparison was made after one time of administration. The effective rates of the treatment group and control group were 93.1% and 94-1% respectively (before vs. after treatment: P<0.01; inter-group comparison; P>0.05). The responding time was 10--40 minutes for both groups but maintenance time was only several minutes in control group and it was 2 hours in treatment groups (P<0.01). Our results showed that the captopril injectio possessed pronounced effect of lowering blood pressure. It has short responding time, long maintenance time and less side-effects.
出处
《药物流行病学杂志》
CAS
1997年第2期68-70,共3页
Chinese Journal of Pharmacoepidemiology
关键词
卡托普利
硝普钠
高血压危象
高血压
治疗
Captopril
Sodium nitroprusside
Hypertensive crisis
Clinical control study
