摘要
肠粘膜屏障功能减弱可导致肠道内内毒素的转运。本研究应用１２５Ｉ－ＬＰＳ作为示踪剂，通过对家兔离体和在体肠袢进行肠腔内施压，动态观察肠腔内毒素向肠外转运的模型，分析和探讨肠腔内压力、施压时间、肠屏障功能与肠内毒素转运的关系。实验结果表明：肠内压的升高可损害肠粘膜屏障，促进肠内毒素向体内的转运。高压力组的１２５Ｉ－ＬＰＳ入血总量明显高于低压力组（Ｐ＜０．０１）；离体肠管１２５Ｉ－ＬＰＳ入血量峰值出现在０．５小时，当肠腔内压大于２０ｃｍＨ２Ｏ时，在体肠管内１２５Ｉ－ＬＰＳ入血峰值向后延迟；肠内压力的升高有助于肠组织吸收１２５Ｉ－ＬＰＳ及肠内１２５Ｉ－ＬＰＳ的肠外渗漏。说明在肠道内内毒素转运过程中，肠内压升高及施压时间与内毒素入血呈正相关，并加重肠屏障的损伤。
he injury of intestinal mucosa barrier function can induce intestinal intraluminal endotoxin translocationModels of rabbits intestines in vitro and in vivowere used with pressure changes in the intestinal lumen and was used 125I-LPS as a tracer for observing and analysing thier relathioship.The results showed:(1)High pressure could damage the intestinal barrier and promote intestinal endotoxin translocation into the blood circulation(P<0.01).(2)The peak of entering into blood circulation of 125I-LPS was found in 0.5 hour.(3)High intraintestinal pressure promoted 125I-LPS absorption and exudation.It was suggested that high intestinal intraluminal pressure with gut endotoxin could damage the intestinal mucosa barrier and the time of high pressure was also a factor in the course of intestinal endotoxin translocation.
出处
《中国中西医结合外科杂志》
CAS
1997年第6期370-373,共4页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
内毒素转运
肠腔内压力
内毒素血症
endotoxin translocation,intestinal barrier,intraintestinal pressure
