摘要
我院１９８８年元月～１９９６年６月，共手术治疗原发性胆囊癌３０例，对３０例切除标本行免疫组化染色，测定Ｐ５３基因蛋白，另取同期３０例胆囊炎胆囊结石病人做对照，结果原发性胆囊癌Ｐ５３表达率为４６．７％，对照组阴性，Ｐ＜０．０５。肿瘤恶性程度越高，Ｐ５３表达率越高。高分化腺癌与低分化腺癌分别为２８．６％、７４．０％。Ｐ５３阳性者预后较差，五年存活率为１５．４％，阴性者为４２．９％。
30 patients with primary cholecystic carcinoma were treated with surgery from Jan.1988 to June,1996,and P53 protein of the resected bladder was detected with immunohistochemical tests simultaneously.It was found that 14 cases(46.7%)were positive and another 30 cases with cholecystitis and cholelithiasis in control group were negative( P <0.05).5 years survival rate in the patients with P53 positive was significantly lower(15.4%)than that in the patients with P53 negative(42.9%).The positive rate of P53 expression in the well differentiated group(28.6%)was also lower than that in the undifferentiated group(74%).
出处
《中国中西医结合外科杂志》
CAS
1997年第4期238-239,共2页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
P53基因
胆囊癌
表达
P53 protein,cholecystic carcinoma,immunohistochemical stain
