摘要
为研究肿瘤坏死因子（ＴＮＦ）在急性坏死性胰腺炎（ＡＮＰ）所致肺损害中的作用，１４只家犬随机分成三组。中药组（ｎ＝５）：ＡＮＰ模型＋大承气汤治疗；盐水组（ｎ＝５）：ＡＮＰ模型＋生理盐水治疗；假手术组（ｎ＝４）。术后测定血清、支气管肺泡灌洗液（ＢＡＬＦ）的ＴＮＦ活性及血清内毒素水平等指标。结果：１．ＢＡＬＦ中ＴＮＦ活性升高较血清中升高更明显。２．中药组术后６、１２小时血清及ＢＡＬＦ中ＴＮＦ活性低于盐水组（Ｐ＜０．０１）。３．术后１２小时中药组肺损害程度明显轻于盐水组。４．盐水组血清ＴＮＦ活性与内毒素水平呈正相关（Ｐ＜０．０５）。结论：ＴＮＦ的过度分泌是ＡＮＰ致肺损害的重要因素；通里攻下法治疗能够减轻ＴＮＦ介导的肺损害程度。
The role of tumor necrosis facfor (TNF) in the occurrence of lung injury during acute necrotizing pancreatitis(ANF) and the therapeutic effect of purgating method in minimizing the severity of lung injury during ANP were studied in experiments with 14 canines The results showed that elevation of TNF activities was more prominent in bronchi alveolar lavage fluid(BALF) than in serum TNF activities in serum at 6,12 hours after the induction of ANP and in BALF were significantly decreased in the treatment group than in the saline control group(P<0 01) Lung injury was significantly alleviated at 12 hours after the induction of ANP in the treatment group than in control A positive correlation between serum TNF activity and endotoxin level was demonstrated in the control(P<0 05) It was suggested that hypersecretion of TNF might be one of the major causes of lung injury during ANP,purgative method was demonstrated to alleviate the degree of lung injury mediated by TNF
出处
《中国中西医结合外科杂志》
CAS
1997年第5期336-339,共4页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
急性
胰腺炎
肺损伤
通里攻下法
大承气汤
acute pancreatitis,lung injury,tumor necrosis factor,purgative(Tong Xia)method,“Da Cheng Qi”mixture
