摘要
本文采用蛙皮素（Ｃａｅｒｕｌｅｉｎ）和内毒素（ＬＰＳ）制作大鼠重型急性胰腺炎（ＳＰ）模型，并观察中药大柴胡汤冲剂（ＤＳ）和前列腺素Ｅ１（ＰＧＥ１）对本实验性胰腺炎的作用。观察指标包括血清ＧＰＴ、ＧＯＴ、淀粉酶、ＴＮＦ－α；肝脏和胰腺血流及病理学检查；２４小时生存率。结果，急性胰腺炎对照组生存率为５５．６％，ＤＳ组为７６．５％（Ｐ＜０．０５ｖｓ对照组），ＰＧＥ１组为７５％。用ＤＳ和ＰＧＥ１能明显降低血清ＧＰＴ、ＧＯＴ、ＴＮＦ－α和淀粉酶水平，并促进肝脏和胰腺的血流。组织病理学检查未达到统计学意义。这些发现提示ＤＳ和ＰＧＥ１对大鼠感染性重性胰腺炎模型有一定的保护作用。两者的作用机理相似，并有一些不同之处，值得进一步研究。
The effects of Dachaihu Tang extract(DS) and Prostagladin E1(PGE 1) on Caerulein(Cn) and Lipopolysaccharide(LPS) induced severe pancreatitis(SP) models in rat were observed.The parameters included serum GPT,GOT,TNF α,Amylase;the blood flow of the liver was done and 24 hours survival rate calculated.The results showed the survival was 55.6% in the control group;76.5% in DS group( P <0.05);and 75.0% in PGE 1 pretreatment with both DS and PGE 1 significantly decreased the levels of serum GPT,GOT,TNF α and Amylase at most of the time points;and the blood flow in liver and pancreas was increasad.Histophathologic examination did not reach statistical significance.These findings indicated that DS and PGE 1 afforded beneficial effects on the septic SP model in rat.The roles of DS and PGE 1 on this model were almost the same,but with some differences,worthing to be investigated furthermore.
出处
《中国中西医结合外科杂志》
CAS
1997年第5期297-300,共4页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
