摘要
目的以姜黄素混悬液为对照,研究姜黄素-聚维酮固体分散体灌胃给药后在小鼠体内的药代动力学。方法按300mg·kg-1的剂量小鼠灌胃姜黄素固体分散体溶液或姜黄素混悬液,采用高效液相色谱法测定血浆中姜黄素含量,用DAS软件拟合房室模型,计算药动学参数。并测定了给药3h时药物的吸收率。结果姜黄素-聚维酮固体分散体在小鼠体内的药代动力学符合二室开放模型,主要药动学参数如下:T12α和T12β分别为16.4和266min,AUC为89.6mg·mL-1.min-1,Vd为763.9L,V1为51.0L,CL为1.99L·min-1。姜黄素-聚维酮固体分散体在胃肠道的吸收率是姜黄素混悬液的6.75倍。结论姜黄素固体分散体灌胃可显著增加姜黄素的生物利用度,血药浓度较高。
Aim To study the pharmacokinetics of curcumin-pvp solid dispersion ig administration in mice in comparison with the free curcumin suspension. Methods Drugs were administered at a dose of 300 mg· kg^-1 via ig. The plasma concentration of curcumin was determined by HPLC, the pharmacokinetics were calculated by DAS verl. 0 program. Results The curcumin pharmacokinetics conforms to a two-compartment open model after a single ig dose of curcumin solid dispersion in mice. The parameters were as follows： T1/2α andT1/2β were 16.4 and 266. 1 min, respectively. AUC was 89. 6 mg · L^-1 · min^-1,Vd was 763.9 L,V1 was 51.0 L,and CL was 1.99 L · min^-1. The absorption rate of cureumin solid dispersion was 6.75 times as much as curcumin suspension. Conclusion The eurcumin solid dispersion improves the absorption of curcumin in vivo in mice evidently.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第11期1525-1527,共3页
Chinese Pharmacological Bulletin
基金
福建省重大专项前期研究项目资助项目(No2005YZ1010)
