摘要
庆大霉素M(4)系首次从小单孢属菌F_(54-37)变异菌株27~#的发酵液中,分得的一种碱性氨基糖苷类抗生素.m.p.120—126℃.C_(21)H_(41)N_4O_8.m/s:491(M^+)。在酸性甲醇溶液中水解降解后,分得2-脱氧链霉胺(5)、加拉霉胺(7)、庆大霉胺(8)和甲基-β-加拉糖胺;结合核磁共振及质谱分析,确定了它的结构为6′-N-乙酰基庆大霉素。
Gentamicins and related antibiotics are basic, water-soluble substances of the aminoglycoside-family produced by Micromonospora mutant 27~#. Gentamicin M (4) a metabolic product of mutant 27~# was shown by proton and ^(13)C NMR as well as mass spectrometry in conjunction with degradation study to be 6'-N-acetylgentamicin.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
1990年第8期815-819,共5页
Acta Chimica Sinica
