摘要
当前人类基因组研究的重心正在由“结构”向“功能”转移。一个以基因组功能研究为主要内容的所谓“后基因组时代”(post-genomics),即功能基因组学(functional genomics)时代即将到来。功能基因组学主要研究基因的识别及其功能信息的提取、鉴定和开发利用,涉及生物信息学、计算机生物学和生物医学研究等领域。其成果将深化对基因组遗传语言,基因结构与功能的关系,生命的起源与进化,细胞发育、生长、分化,以及疾病发生、发展的分子机理等问题的理解。功能基因组学的研究还将促进生命科学与数学、物理、化学、信息科学、计算机科学以及自动化技术等学科的交叉融汇,刺激相关学科技术领域的发展。
With the completion of the sequencing of the yeast genome last year and the sequencing of several other genomes on track, what has been termed ' the post-genomic era looms ever closer, and questions of what this means and where it will lead to become paramount (Editorial, 1997, Nat Genet, 15, 111). Bioinformatics and computational biology are needed for transcrip-tional analysis. Characterization of potential regulatory elements in genomic DNA remains a difficult task. As the analysis of genomes moves into large-scale sequencing, identification and annotation of biologically relevant features in the sequence become increasingly complex and important. A combination of experimental and theoretical approaches will be brought to bear on these challenges.
出处
《中国科学基金》
CSCD
1997年第4期267-272,共6页
Bulletin of National Natural Science Foundation of China
