摘要
微RNA(microRNA,miRNA)是一种内源性非编码小RNA,在转录后水平调控基因表达,在肿瘤的发生发展过程中起重要作用。p53是重要的抑癌基因,在DNA损伤和癌基因等刺激下活化,诱导下游基因表达,使细胞周期阻滞、DNA修复并促进细胞衰老或凋亡。本文主要介绍近期发现的直接受p53调控的miR-34基因家族,及其在生长阻滞和细胞凋亡方面的研究进展,揭示了蛋白质与非编码RNA在重要的p53抑癌网络中的相互关系,为肿瘤的研究提供了新的思路。
MicroRNA is a kind of small, endogenous non-coding RNA. It can regulate gene expression in post-transcription level, which plays a vital role in tumorigenesis and development. The tumor suppressor gene p53, which is activated by DNA injury and oncogenes, can induce downstream genes expression, leading to cell cycle arrest, DNA repair, cell senescence and apoptosis. This review highlights the miR-34 gene family as direct, conserved p53 target gene that presumably mediates the induction of cell arrest and apoptosis by p53. It reveals the important relationship between protein and non-coding RNA in the well-known tumor suppressor network, which probably provides a new way for cancer research.
出处
《生命的化学》
CAS
CSCD
北大核心
2008年第5期544-548,共5页
Chemistry of Life
