摘要
目的探讨急性心肌梗死（AMI）患者的高敏C反应蛋白（hs—CRP）等炎性指标水平和左心室室壁瘤（LVA）形成的关系。方法将68例AMI患者经心脏超声和（或）左心室造影检查确诊为LVA形成，并符合纳入标准的患者分为LVA组，另设68例为对照组行配对研究，测定血清hs—CRP、血沉（ESR）、白细胞（WBC）计数和中性粒细胞百分率，并做超声心动图和（或）左心室造影检查，评定左心室功能和室壁运动情况。结果LVA组患者的血清hs—CRP、ESR、中性粒细胞百分率明显高于对照纽（P〈0．001），WBC虽高于对照组，但差异无统计学意义（P〉0．05）。结论hs—CRP炎性指标水平增高与AMI后LVA形成密切相关。
Objective To explore the relationship between inflammation indexes, such as high sensitivity C-reactive protein （hs-CRP）, erythrocyte sedimentation rate （ESR）, white blood cell （WBC） and neutrophil,and left ventricular aneurysm（LVA） formation in patients with acute myocardial infarction（AMI）. Methods Paired case-control study on 68 cases of AMI with LVA and 68 cases of AMI without LVA was used to analyse the inflammation indexes,image parameters of echocardiogram and left ventriculogram in the two groups. The image parameters included left ventricle end-systolic diameter （LVESD）, left ventricle end-diastolic diameter （LVEDD）, left ventricle ejection fraction,wall motion segment index by echocardiography, and left ventricle endsystolic volume, left ventricle end-diastolic volume, wall motion segment index by left ventriculography. Results The levels of hs-CRP, ESR and neutrophil count were significantly higher in AMI with LVA than in AMI without LVA （P %0. 001）. The levels of WBC were also higher in AMI with LVA than in AMI without LVA （P 〉0.05）. Left ventricle diameter and volume, ejection fraction, wall motion segment index were significantly higher in AMI with LVA than in AMI without LVA （P〈0. 001）. Conclusion Elevation of inflammation index levels is closely associated with the formation of LVA after AMI.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2008年第11期824-826,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
教育部博士点专项基金（20060023044）
关键词
心肌梗塞
C反应蛋白质
心脏室壁瘤
炎症
myocardial infarction
C-reactive protein
heart aneurysm
inflammation
