摘要
目的：为探讨烧伤脓毒症的防治措施，采用烫伤后盲肠结扎穿刺术建立烧伤脓毒症小鼠模型。方法：体外观察ｒＩＬ－２（重组白细胞介素２）对鼠模型和临床烧伤患者的细胞免疫功能的作用。结果：①烧伤脓毒症小鼠脾细胞对ＣｏｎＡ刺激的应答和ＮＫ细胞毒活性均显著降低；②烧伤患者的Ｔ细胞和ＮＫ细胞免疫功能也明显降低，并随烧伤严重程度而加重；③ｒＩＬ－２在体外对烧伤后受损的细胞免疫功能有一定的改善作用，但对脓毒症感染患者无明显作用。结论：ｒＩＬ－２对烧伤后免疫功能的降低有一定的恢复作用。
AIM: To study the prevention and treatment of rIL 2 on postburn sepsis. METHODS: The method of burn and cecal ligation puncture (CLP) to reconstruct model in mice were used and the effects of rIL 2 on the cellular immune function in murine models and patients were observed in vitro. RESULTS: ① the mitogen stimulating murine splenocytes proliferation and NK cytotoxicity in burn sepsis mice were remarkably impaired;② the immune function of PBMC and NK cell in burned patients were also reduced and were related to burn severe extent;③ exogenous recombinant IL 2 (rIL 2) induced enhancement of PBMC proliferation and NK activity except sepsis patients. CONCLUSIONS: It is suggested that rIL 2 might have some effects on improving the impaired immune function after thermal injury.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1997年第4期355-357,共3页
Chinese Pharmacological Bulletin
