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大肠癌组织中促红细胞生成素受体表达与微血管密度的关系 被引量：1

Relationships of erythropoietin receptor expression and microvascular density in colorectal carcinoma tissues
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摘要 目的:探讨大肠癌组织中促红细胞生成素受体(erythropoietin receptors,Epo-R)表达与肿瘤微血管密度(microvessel density,MVD)和临床病理特征的关系。方法:采用免疫组织化学SP法对60例大肠癌组织、20例正常大肠组织中Epo-R和MVD进行检测。结果:60例大肠癌组织均检测到Epo-R的表达。大肠癌组织MVD值为30.8±9.5,显著高于正常大肠组织的4.1±2.5(P<0.01)。MVD水平与大肠癌患者年龄、肿瘤浸润深度、淋巴结转移、远处转移、临床分期有显著相关性(P<0.05)。Epo-R表达与大肠癌组织MVD成正相关。结论:Epo-R在大肠癌组织中有异常高表达,且与MVD和临床病理特征成正相关,可能在肿瘤新生血管形成中有重要作用。 Objective：To investigate the correlation between erythropoietin receptor（Epo-R）expression and microvascular density（MVD）in colorectal carcinoma tissues.Methods：Expression of erythropoietin receptor and microvascular density in 60 specimens of colorectal carcinoma and 20 normal colorectal specimens were investigated by immunohistochemistry.Results：Epo-R expression was found in all the colorectal carcinoma tissues.The level of MVD was much higher in colorectal carcinoma than that in the corresponding normal tissues（30.8±9.5 vs 4.1±2.5（P〈0.01）.Moreover,the level of MVD was significantly correlated with the patient age,depth of tumor invasion,lymph node metastasis,distant metastasis,clinical stage（P〈0.01）.The expression of Epo-R was positively correlated with MVD（P〈0.01）.Conclusion：Epo-R expression is upregulated,which is positively correlated with MVD and clinical pathological characteristics.
作者 方文成 崔红侠 孙卫红 寇治民
机构地区 山东省日照市人民医院普外科 兰州大学第二医院普外科
出处 《中国现代普通外科进展》 CAS 2008年第5期402-404,共3页 Chinese Journal of Current Advances in General Surgery
关键词 大肠肿瘤 促红细胞生成素受体 微血管密度 Colorectal carcinoma·Erythropoietin receptor·Microvascular density
分类号 R735.3 [医药卫生—肿瘤]
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参考文献8

  • 1Lappin TR, Maxwell AP, Johnston PG. Epos alter ego: erythropoietin has multiple actions[J].Stem Cells, 2002,20(6):485-492.
  • 2Weidner N. intratumor microvessel density as a prognostic factor in cancer[J]. Am J Pathol, 1995,147(1):9-19.
  • 3Batra S, Perelman N, Luek LR, et al. Pediatric tumor cells express erythropoietin and a functional erythropoietin reeeptor that promotes angiogenesis and tumor cell survival [J]. Lab Invest, 2003,83 (10): 1477-1487.
  • 4Ribatti D, Marzullo A, Nico B, et al. Erythropoietin as an angiogenic factor in gastric carcinoma[J]. Histopathology, 2003,42(3):246-250.
  • 5Areasoy M, Amin K, Karayal AF, et al. Functional significance of erythropoietin receptor expression in breast cancer [J]. Lab Invest, 2002,82(7):911-918.
  • 6Pollio F, Staibano S, Mansuero G, et al. Elythropoietin and erythropoi- etin receptor system in a large uterine myoma of a patient with myomatous erythrocytosis syndrome: possible relationship with the pathogenesis of unusual tumor size[J]. Hum pathol, 2005,36(1):120-127.
  • 7Vermeulen PB, Van den Eynden GG, Huget P, et al. Prospective study of intratumoral microvessel density, p53 expression and survival in colorectal cancer[J]. Br J Cancer, 1999,79(2):316-322.
  • 8Tsuji T, Sasaki Y, Tanaka M, et al. Mierovessel morphology and vascular endothelial growth factor expression in human colonic carcinoma with or without metastasis[J]. Lab Invest, 2002,82(5):555-562.

同被引文献25

  • 1Sasaki R,Masuda S,Nagao M.Erythropoietin:multiple physiological functions and regulation of biosynthesis[J].Bios Biot Biochem,2000,64(9):1775-1793.
  • 2Yasuda Y,Hara S,Hirohata T,et al.Erythropoietin-responsive sites in normal and malignant human lung tissues[J].Anat Sci Int,2010,85(4):204-213.
  • 3Chen C,Sytkowski AJ.Erythropoietin activates two distinct signaling pathways required for the initiation and the elongation of c-myc[J].J Biol Chem,2001,276(42):38518-38526.
  • 4Yasuda Y,Fujita Y,Matsuo T,et al.Erythropoietin regulates tumour growth of human malignancies[J].Carcinogenesis,2003,24(6):1021-1029.
  • 5Papworth K,Bergh A,Grankvist K,et al.Expression of erythropoietin and its receptor in human renal cell carcinoma[J].Tumor Biol,2009,30(2):86-92.
  • 6Giatromanolaki A,Fiska A,Pitsiava D,et al.Erythropoietin receptors in endometrial carcinoma as related to HIF1α and VEGF expression[J].In Vivo,2009,23(5):699-703.
  • 7Küster O,Simon P,Mittelbronn M,et al.Erythropoietin receptor is expressed in meningiomas and lower levels are associated with tumour recurrenc[J].Neuropathol Appl Neurobiol,2009,35(6):555-565.
  • 8Sinclair AM,Rogers N,Busse L,et al.Erythropoietin receptor transcription is neither elevated nor predictive of surface expression in human tumour cells[J].Br J Cancer,2008,98(6):1059-1067.
  • 9Zhong H,De Marzo AM,Laughner E,et al.Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases[J].Cancer Res,1999,59(22):5830-5835.
  • 10Acs G,Acs P,Beckwith SM,et al.Erythropoietin and erythropoietin receptor expression in human cancer[J].Cancer Res,2001,61(9):3561-3565.

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中国现代普通外科进展
2008年 第5期

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