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固有免疫模式受体NALPs的信号通路及其与自身免疫性疾病的研究进展 被引量：1

Progresses on innate cytosolic pattern-recognition receptor NALPs signal transduction pathway and some immunity diseases
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摘要 随着对固有免疫模式受体（NALPs）家族蛋白研究的深入，人们了解到NALPs家族蛋白与Toll样受体一样广泛参与对病原体的识别及免疫应答。免疫性疾病与NALPs家族蛋白尤其是NALP1和NALP3相关。本文主要介绍了NALPs家族蛋白的结构、分布、识别配体及信号通路，探讨了NALP1和NALP3在免疫炎症反应中的机制及其与免疫性疾病中的作用。 With the study of the NACHT Leucine-rich-repeat proteins family （ NALPs）, the NALP are recognised as Toll-Li ke receptors which play important roles in innate immunity as sensors of bacterial components. And the discovery of the NALPs system has provided a new insight into the mechanism that control and activation of the inflammasome. The NALPs family, especially NALP1 and NAPL3, are highly related to immunity diseases. This paper introduce structure, distributing, identify and signaling pathways of the NALPs proteins family. And it mainly discusses how NALP1 and NALP3 operate in inflammation immunity reaction and theirs intimate relation with immunity disease. Better understanding of the mechanism might open the door to new therapeutic approaches for the treatment of those diseases.
作者 林福全
机构地区 浙江理工大学生物工程研究所硕士研究生
出处 《国际免疫学杂志》 CAS 2008年第6期419-422,共4页 International Journal of Immunology
基金 国家自然科学基金项目资助（30671896） 浙江省自然科学基金资助项目（Z206607）
关键词 NALPs 信号通路 免疫性疾病 NACHT leucine-rich-repeat proteins Signaling pathways Immunity diseases
分类号 R593 [医药卫生—内科学]
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  • 1王菲,冯永堂（审校）.TLR家族分子信号转导新进展[J].国外医学（免疫学分册）,2005,28(5):313-316. 被引量：15
  • 2Gondokaryono SP,Ushio H,Niyonosaba F,et al. The extra domain A of fibronectin stimulates murine mast cells via Toll-like receptor 4. Journal of Leukocyte Biology ,2007,82 (3) :657-665.
  • 3Bobacz K,Sunk I. G,Hofstaetter J. G, et al. Toll-like receptors and chondrocytes: the lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of Toll-like receptor 4 and antagonized by bone morphogenetic protein 7. Arthritis & Rheumatism, 2007,56 ( 6 ) : 1880 - 1893.
  • 4Seibl R, B irchler T, Loeliger S, et al. Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium. Am J Pathol, 2003,162(4) :1221-1227.
  • 5Pierer M, Rethage J, Seibl R, et al. Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands . J Immunol, 2004,172(2) :1256-1265.
  • 6Muzio M, Mantovani A. Toll-like receptors. Microbes Infect,2000,2 (3) :251-255.
  • 7Ozinsky A, UnderhiU DM, Fontenot JS, et al. The repertoire for pattern recognition Of pathogens by the innate immune system is defined by cooperation between toll-Like receptors. Prec Natl Acad Sci USA, 2000,97(25) :13766-13771.
  • 8Hoebe K , Du X, Georgel P, et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature, 2003,424 (6950) :743-748.
  • 9Ehrhardt C, Kardinal C, Wurzer W J. Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3. FEBS Lett, 2004,567(2-3) :230-238.
  • 10Kariko K, Ni H, Capodici J,et al. mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem, 2004,279(13) :12542-12550.

共引文献3

同被引文献11

  • 1Strowig T,Henao-Mejia J,Elinav E,et al.Inflammasomes in healthand disease[J].Nature,2012,481(7381):278-286.
  • 2Hooper DC,Spitsin S,Kean RB,et al.Uric acid,a natural scavenger ofperoxynitrite,in experimental allergic encephalomyelitis and multiplesclerosis[J].Proc Natl Acad Sci USA,1998,95(2):675-680.
  • 3Gris D,Ye Z,Iocca HA,et al.NLRP3 plays a critical role in the de-velopment of experimental autoimmune encephalomyelitis by mediatingTh1 and Th17 responses[J].J Immunol,2010,185(2):974-981.
  • 4Guarda G,Braun M,Staehli F,et al.Type I interferon inhibits inter-leukin-1 production and inflammasome activation[J].Immunity,2011,34(2):213-223.
  • 5Dong M,Liu R,Guo L,et al.Pathological findings in rats with experimen-tal allergic encephalomyelitis[J].APMIS,2008,116(11):972-984.
  • 6Ting JP,Davis BK.CATERPILLER:a novel gene family important inimmunity,cell death,and diseases[J].Annu Rev Immunol,2005,23:387-414.
  • 7Lalor SJ,Dungan LS,Sutton CE,et al.Caspase-1-processed cytokinesIL-1beta and IL-18 promote IL-17 production by gammadelta and CD4T cells that mediate autoimmunity[J].J Immunol,2011,186(10):5738-5748.
  • 8Martinon F,Burns K,Tschopp J.The inflammasome:a molecularplatform triggering activation of inflammatory caspases and processingof proIL-beta[J].Mol Cell,2002,10(2):417-426.
  • 9Chung Y,Chang SH,Martinez GJ,et al.Critical regulation of earlyTh17 cell differentiation by interleukin-1 signaling[J].Immunity,2009,30(4):576-587.
  • 10Sims JE,Smith DE.The IL-1 family:regulators of immunity[J].NatRev Immunol,2010,10(2):89-102.

引证文献1

国际免疫学杂志
2008年 第6期

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