摘要
目的探讨结核性脑膜炎预后的影响因素。方法56例诊断为结核性脑膜炎的患者，依其应用正规强化抗结核治疗三个月的转归分为预后好和预后差两组。记录患者的9个参数：性别、年龄、临床分期、第一次脑脊液的蛋白含量、第一次腰穿的压力、血钠的浓度、头部磁共振是否发现局限性病灶、强化期是否合用激素、是否使用脑脊液置换并鞘注治疗。用单变量logistic回归分析得出与结核性脑膜炎预后显著相关的变量，后用多变量stepwise logistic回归分析得出结核性脑膜炎预后的最佳回归方程。结果Logistic回归分析表明与结核性脑膜炎预后显著相关的独立变量包括：临床分期、第一次脑脊液的蛋白含量、血钠的浓度、强化期是否合用激素、是否使用脑脊液置换并鞘注治疗。结论在正规抗结核治疗的基础上联合脑脊液置换并鞘注治疗可改善结核性脑膜炎患者的预后。
Objective To explore the factors that Influencing prognosis of cerbral tuberculosis. Methods We studied 56 Cerbral tuber- culosis impatients to devide into the good prognosis and bad prognosis after the regularity theropy with antituberculosis drugs. And record 9 Parameters with inpatients ： gender, Age, clinical stage, the protein level of first CSF, the pressure of the first lumbar puncture, the level of sangui - sodium, the imaging of MRI,the use of hormone, the use of cerebrospinal fluid replacement combining intrathecal pouring leechdom on CNS biochemistry. To get the obviously variable with the prognosis of cerbral tuberculosis by single variable logistic Regression Analysis ; To get the best equation by Multivariable stepwise logistic Regression Analysis. Result The ohviously variable with the prognosis of cerbral tuberculosis is clinical stage ,the protein level of first CSF, the level of sangui - sodium,the use of hormone ,The use of cerebrospinal fluid replacement combining intrathecal pouring leechdom on CNS biochemistry. Conclusions The use of cerebrospinal fluid replacement combining intrathecal pouring leechdom on CNS biochemistry combing the regularity theropy with antituberculosis drugs can improing the prognosis of cerbral tuberculosis.
关键词
结核性脑膜炎
预后
Cerbral tuberculosis Prognosis
