摘要
目的:综述鼻NK/T细胞淋巴瘤的诊断和治疗,探讨其更合理的治疗方案,为提高疗效改善患者预后提供理论依据。方法:应用计算机检索NC-BI Entrez PubMed和CNKI数据库2001-2007有关鼻NK/T细胞淋巴瘤的研究文章,检索词为"鼻NK/T细胞淋巴瘤、诊断、放疗和化疗",排除个案报道、重复研究类文章。共收集分析文献28篇。结果:NK/T细胞淋巴瘤在WHO新分类中被命名为"结外NK/T细胞淋巴瘤,鼻和鼻型",亚洲地区发病率明显高于西方国家。单纯化疗特别是含蒽环类的常规化疗方案疗效较差,非蒽环类化疗方案的结果具有显著优势。放疗为主的治疗结果优于单纯化疗。结论:ⅠE/ⅡE期患者应首选放疗,化疗可能更适合那些超腔组、非鼻侵袭型或晚期患者。最佳化疗方案可能不是含蒽环类方案,建议考虑非蒽环类方案。放化疗联合的综合治疗结果要好于单纯化疗,但与单纯放疗相比有一定争议,有待进一步进行多因素分层分析研究。
OBJECTIVE：The literature of nasal natural killer cell（NK/T cell） lymphoma about diagnosis and therapy was reviewed,so as to investigate the reasonable therapeutic regimen and improve the patient＇s curative effect and survival.METHODS： Articles on diagnosis and therapy of nasal natural killer cell（NK/T cell） lymphoma published between January 2001 and January 2007 were retrieved in NCBI Entrez PubMed and CHKI with the of ＂lymphoma,extranodal NK T cell,nasal cavity,diagnosis,drug therapy and radiotherapy＂.Twenty-eight articles were selected by primary choice.RESULTS： The nasal natural killer cell（NK/T cell） lymphoma is classified by the World Health Organization as extranodal NK/T-cell lymphoma,nasal type.It is prevalent in Asia,but exceptionally rare in western countries.The patients received chemotherapy alone,especially conventional anthracycline-based chemotherapy,have a poor response,and can not compare with the affection of nonanthracycline-based chemotherapy.The result of radiotherapy-based regiment shows a potential survival advantage contrasted with alone chemotherapy.CONCLUSIONS： The primary treatment of the patient with ⅠE/ⅡE stage should consist of radiotherapy.Chemotherapy could refer to the patients with the lesion beyond the nasal cavity,non-nasal type,and advanced stage.Conventional anthracycline-based chemotherapy can not campare with nonanthracycline-containing chemotherapy as the first-rate chemotherapy regimen.The consequence of the combined chemoradiotherapy surpasses the pure chemotherapy,nevertheless,it is still controversial as compared with pure radiotherapy.The analysis of subset by assessing prognostic factors should be performed.
出处
《中华肿瘤防治杂志》
CAS
2008年第18期1429-1432,共4页
Chinese Journal of Cancer Prevention and Treatment
