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BCL3基因多态性与非综合征性唇、腭裂相关性的研究 被引量：1

Association between Nonsyndromic Cleft Lip Only or Cleft palate Only and B-cell Leukemia/lymphoma 3 Polymorphisms in the Chinese
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摘要 目的:探讨B细胞淋巴因子-3基因多态性与中国人群非综合征性唇裂及腭裂发生的相关性。方法:应用聚合酶链式反应和聚丙烯酰胺变性凝胶技术,以103名健康体检者为对照,对50名单纯唇裂及50名单纯腭裂患者进行研究,分析BCL3基因多态性。结果:检测出BCL3的3种等位基因,全部基因型都是杂合子。患病组与对照组比较(χ2=13.829,df=2,P<0.01),单纯唇裂组与对照组比较(χ2=1.459,df=2,P>0.05)。单纯性腭裂组与对照组比较(χ2=23.225,df=2,P<0.01)。单纯唇裂组与单纯腭裂组比较(χ2=8.392,df=2,P<0.05)。结论:BCL3基因与中国人群非综合征性单纯性腭裂的发生有相关性,而与非综合征性单纯唇裂的发生无明显相关性。 Objective： To study the relationship between B -cell leukemia/lymphoma 3 （B -cell leukemia/lymphoma 3, BCL3 ） polymorphisms and nonsyndromic cleft lip only or cleft palate only in the Chinese. Methods： BCL3 was examined by PCR and denaturing polyacrylamide gel electrophoresis technique in the 50 cleft lip only patients, 50 cleft palate only patients and 103 healthy persons. Results： The comparison between the control and the cleft lip only patients was χ^2 = 1. 459, df = 2, P 〉 0. 05. The result between patients who had cleft palate only and the control was χ^2 = 23. 225, df = 2, P 〈 0.01. And the comparison between nonsyndromic cleft lip only and cleft palate only was significant. Conclusion： There was association between nonsyndromic cleft palate only and BCL3 polymorphism in Chinese, while there was no association between nonsyndromic cleft lip only and BCL3 polymorphisms.
作者 静广平 焦晓辉
机构地区 哈尔滨医科大学附属口腔医院
出处 《口腔医学研究》 CAS CSCD 2008年第5期517-519,共3页 Journal of Oral Science Research
关键词 唇裂 腭裂 遗传学 B细胞淋巴因子-3 多态性 Cleft lip Cleft palate Genetics B - cell leukemia/lymphoma 3 Polymorphism
分类号 R782.2 [医药卫生—口腔医学]
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参考文献18

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二级参考文献26

共引文献47

同被引文献49

  • 1静广平,焦晓辉.非综合征性唇腭裂与BCL3基因多态性的研究[J].口腔医学研究,2005,21(2):156-159. 被引量：10
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口腔医学研究
2008年 第5期

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