摘要
过氧化物酶体增殖物激活受体-δ(PPARδ)激动剂在代谢疾病的动物模型中具有重要作用。近年来,在鼠及非人灵长类动物实验中发现用PPARδ激动剂可使血脂正常化,减轻胰岛素抵抗和肥胖。PPARδ活化通过调节骨骼肌中线粒体氧化能力、葡萄糖-胰岛素循环增强葡萄糖利用,以及减少三酰甘油的沉积而减轻胰岛素抵抗;并且PPARδ激动剂可降低血循环中胰岛素水平,使胰岛素对葡萄糖的敏感性增加,改善糖耐量。作者就PPARδ的结构及其与代谢紊乱的关系等方面作一综述。
Synthetic agonists of peroxisome proliferator-activated receptors-δ（PPARδ） have an important role in the preclinical models of metabolic diseases.In the recent years,it has been demonstrated that PPARδ agonists can normalize blood lipids and reduce insulin resistance and adiposity in rodents and primates.PPARδ activation in the skeletal muscle regulates the oxidative capacity of the mitochondrial apparatus,switches fuel preference from glucose to fatty acids and reduces triacylglycerol storage.PPARδ agonists also reduce insulin levels in serum,increase the sensitivity of insulin and improve glucose-tolerance.The genetic polymorphism in PPARδ has been shown to be associated with blood lipids,obesity and type 2 diabetes.
出处
《医学研究生学报》
CAS
2008年第10期1109-1112,共4页
Journal of Medical Postgraduates
基金
南京市医学科技发展计划基金资助项目(批准号:ZKX05022)
