摘要
采用重组基因工程干扰素α－2b分别以两种剂量治疗慢性乙型肝炎（CHB）254例，其中甲组130例，每次100万单位，乙组124例，每次300万单位，隔日一次肌注，连用3个月，观察两种剂量的干扰素对CHB疗效的影响。结果血清ALT及胆红素复常率乙组高于甲组，统计学处理两组差异显著（P＜0.05），HBV－M结果示HBeAg、抗－HBcIgM、HBV－DNA阴转率及抗－HBe阳转率乙组亦优于甲组（P＜0．05），说明适当增加干扰素剂量，可提高对CHB的疗效．但大利量干扰素亦可增加不良反应应予以注意。
254 cases of chronic hepatitis B had been treated with two dosage recombinant interferon α-2b from Jan 1994 to Feb 1996. These patients were divided into twogroups:Group A(n=130) subjected to IFN α-2b(lmu),and Group B (n=124) subjected to IFA α-2b (3mu). IFN α-2b had been intramuscularly injected every other day forthree months in order to compare with the efficiency of two dosage IFA α-2b in treatingpatients with chronic hepatitis B. The two groups were comparable in their clinical type,course of disease age,sex, ALT' level and HBVM ect. And half a year for and been followed after their termination of therapy. The results suggest that the recovery rate ofserum ALT leveI and TBil in Group B is superior to that in Group A(P<0. 05). At onetime,The negativity rate of HBeAg,anti-HBe seroconversion in Group B is superior tothat in Group A(P<0. 05). All these suggest that treatment efficiency to CHB can beimproved if you increase dosage suitably. But harmful reflection can also be improvedwith large amaunt of dosage,which should be noticed.
出处
《临沂医学专科学校学报》
1997年第3期183-185,共3页
Journal of Linyi Medical College
关键词
治疗
干扰素
乙型肝炎
剂量
Interferon α-2b
chronic hepatitis B
Dosage
