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结直肠癌中CDX2的表达及其与浸润转移的关系

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摘要 目的研究CDX2在结直肠癌中的表达及其与浸润转移的关系。方法收集65例结直肠癌及其配对的癌旁正常组织标本,采用免疫组化SP法检测标本中CDX2蛋白的表达。结果CDX2蛋白在58例(89.2)结直肠癌组织表达阳性,64例(98.5)正常组织表达阳性,差异有显著性(P<0.05);CDX2的表达与肿瘤的分化程度、Dukes分期、有无淋巴结转移明显相关(P<0.05),而与患者的年龄、性别、肿瘤的部位无相关性(P>0.05)。结论CDX2的异常表达可能在结直肠癌的发生发展、浸润转移中起着重要作用,检测结直肠癌中CDX2的表达对结直肠癌病理特征的分析及判断患者的预后有一定的意义。
作者 陈新岐 曹杰 李旺林 杨平 谭明华 唐伟镖 陈伟
机构地区 广州医学院附属市一人民医院胃肠外科
出处 《广东医学》 CAS CSCD 北大核心 2008年第11期1886-1887,共2页 Guangdong Medical Journal
关键词 结直肠肿瘤 CDX2 免疫组化
分类号 R574.62 [医药卫生—消化系统] R735.3 [医药卫生—肿瘤]
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参考文献6

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二级参考文献15

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共引文献8

广东医学
2008年 第11期

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