摘要
目的观察娑罗子提取物对实验小鼠胃肠道的影响。方法采用易蒙停建立小鼠便秘模型和肠蠕动抑制模型,通过鼠肠道炭末推进法测定小鼠排便和小肠推进,观察不同剂量组(3.5,7,14 mg/kg)娑罗子提取物对便秘小鼠的首次排便时间、粪便粒数、粪便重量和小肠内容物推进率的影响;采用无水乙醇造成小鼠急性胃粘膜损伤,观察娑罗子提取物各组溃疡指数、溃疡抑制率的变化。结果与模型组比较,娑罗子提取物各剂量组均能明显提高小肠推进率(P<0.05),显著减少溃疡指数(P<0.01),低,中,高各剂量组溃疡抑制率分别达到75.2%,77.0%,72.9%;低剂量组能显著增加小鼠粪便粒数(P<0.01)和粪便重量(P<0.05)。结论娑罗子提取物对实验小鼠胃肠道具有明显的保护作用。
Objective To study the effects of extracts from Semen Aesculi on gastric mucosa, gastrointestinal transit and constipation in mice. Methods The time of the first black stool, the number of stool, the weight of stool and the propulsive rate of intestines in mice were observed following the constipation induced by loperamide,and the gastric ulcer indices induced by ethanol in mice were also evaluated. Results Extracts of Semen Aesculi at low - dose increased the amount of stool granule （ P 〈 0. 01 ） and the weight of stool （P 〈 0. 05 ）, attenuated the decreased propulsive rate of intestines（P 〈 0. 05）, and potently inhibited ethanol - induced gastric mucosal lesions （P 〈 0.01 ）. The inhibitory rates of gastric ulcers in low - dose, mid - dose, high - dose groups were 75.2%, 77.0% and 72.9%, respectively. Conclusion Extracts of Semen Aesculi have gastrointestinal protective effects.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第10期2493-2494,共2页
Lishizhen Medicine and Materia Medica Research
关键词
娑罗子
便秘
小肠推进
溃疡指数
Semen Aesculi
Constipation
The propulsive rate of intestines
Ulcer indices
