摘要
选用可降解聚合物PLA,PLGA和固体脂三硬脂酸甘油酯、三嵛酸甘油酯为载体,制备包载布洛芬药物的载药微粒。通过DSC、XRD等测试分析和计算机介观模拟,从载体与药物的相容性、药物在载体中的分布状态等,探讨了载体材料对药物包封率和释放性能的影响。药物与载体的相容性好有利于药物的包封;药物均匀分布在载体中,将减缓药物的释放速率。以三硬脂酸甘油酯、三嵛酸甘油酯为载体时,药物分布在载体的外层空间,以PLA,PLGA为载体时,药物分布在载体内部,结果显示,聚合物载药微粒体外释放速率小于固体脂载药微粒。因而聚合物载药微粒更适合需要长时间缓慢释放的情况。
The ibuprofen-loaded microparticles were prepared with poly（D,L-lactide） （PLA）, poly（D,L-lactide-co-glycolide） （PLGA）, tristearin and glyceryl behenate （Compritol） as carrier materials, respectively. The compatibility and the distribution between the carriers and ibuprofen were investigated by DSC, XRD and DPD （dissipative particle dynamics） simulation technique. The entrapment efficiency and release performance of the drug-loaded microparticles were also studied. The better compatibility between the drug and the carrier can cause the drug-loaded microparticles to have a higher entrapment efficiency of the drug, and the more uniform dispersion of the drug molecules in the carrier matrix can cause the drug-loaded microparticles to have a sustained release performance. The DPD simulation shows that the ibuprofen molecules are distributed in the inner area of the carrier matrix when PLA or PLGA is used as carrier, while they will be adsorbed on the surface or distributed in the outer area of the carrier matrix when tristearin or Compritol is used as carrier. It shows that the in vitro ibuprofen release of the polymeric PLA or PLGA microparticles is slower than that of tristearin or Compritol microparticles. Therefore the polymeric microparticles are more suitable to be used as the carrier for drug-loaded microparticles with long term sustained release preformance.
出处
《高校化学工程学报》
EI
CAS
CSCD
北大核心
2008年第5期791-796,共6页
Journal of Chemical Engineering of Chinese Universities
基金
国家自然科学基金(20476033
20536020
20776049)
