摘要
目的:制备更昔洛韦肺部靶向微囊并测定其体外释放度。方法:以双乳化溶剂挥发法制备微囊;采用紫外分光光度法测定微囊的体外释药量,考察其体外释放度。结果:所制微囊外观圆整,平均粒径13.87μm;更昔洛韦检测浓度的线性范围为2～20μg·mL-1(r=0.999 9),平均回收率为99.96%(RSD=1.68%);包封率为63.85%,24h累积体外释放度约为40%。结论:更昔洛韦肺部靶向微囊具有良好的缓释性。
OBJECTIVE： To prepare and establish a release rate method for the determination of ganciclovir brag - targeted microcapsules. METHODS： The microcapsules were prepared by compound emulsion- dispersion solvent evaporation method. The in vitro drug release amount and release rate of the microcapsules were detected by UV spectrophotometry. RESULTS： The microcapsules were regular in shape with an average particle size of 13.87μm. The linear range of ganciclovir was 2-20 μg · mL^-1（ r = 0.999 9） and its average recovery was 99.96% （RSD = 1.68% ） . The entrapment efficiency of the microcapsules was 63.85% and the drug release amount in vitro reached 40% in 24 hours. CONCLUSIONS： The microcapsules show significant sustained release character.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第31期2447-2448,共2页
China Pharmacy
关键词
更昔洛韦
肺部靶向微囊
溶剂挥发法
体外释放度
Ganciclovir
Lung - targeted microcapsule
Solvent evaporation method
Release rate in vitro
