摘要
目的考察大豆肽对大鼠血压的作用及作用机制,为大豆肽的进一步开发应用提供理论依据。方法静脉给予正常大鼠及急性肾性高血压大鼠一定剂量的大豆肽,采用四道生理记录仪记录其收缩压(SBP)、舒张压(DBP)的变化,采用DFM-96型10管放射免疫γ计数器,利用放免法检测其血浆中血管紧张素(Ang)Ⅰ、Ⅱ的水平。结果分别静脉给予大豆肽1.25,5.0,12.5mg/kg,使急性肾性高血压大鼠SBP由123.7±15.01mmHg分别降至112.25±10.16、110.88±8.87、100.38±6.99mmHg,(P<0.01)、DBP分别由93.63±12.76mmHg分别降至86.13±9.39、84.62±9.2、78.25±6.71mmHg,(P<0.01)和急性肾性高血压大鼠血浆AngⅡ由704.18±90.5pg/ml分别降至587.1±69.74、380.41±70.96、293.1±80.3pg/ml,(P<0.01)水平明显降低。结论大豆肽具有降低急性肾性高血压大鼠血压的作用,其降压作用是通过降低血浆AngⅡ的水平而实现的。
Objective To investigate the effects and mechanism of soy peptides on blood presure and provide a theoretical basis for soy peptides exploration. Method Normal and renal hypertensive rats were used to examine the effects of soy peptides on blood pressure and serum angiotensin （Ang） Ⅰ, Ⅱ in vivo. Use 4 physiological recorder to assay systolic blood pressure （SBP） and diastolic blood pressure （DBP）. Use DFM-96 7 counter to record Ang Ⅰ and Ⅱ. Results Soy peptides 1.25, 5.00, 12.5mg/kg could depress SBP（from 123.7±15.01 mmHg to 112.25±10.16, 110.88±8.87,100.38±6.99 mmHg, P〈0.01）, DBP （from 93.63±12.76 mmHg to 86.13±9.39, 84.62±9.2, 78.25±6.71mmHg, P〈0.01） and serum Ang Ⅱ level （from 704.18±90.5 pg/ml to 587.1±69.74,380.41±70.96,293.1±80.3pg/ml, P〈0.01 ）in hypertensive Wistar rat. Conclusion Soy peptides could depress blood pressure of renal hypertensive rat through elevating serum Ang Ⅱ level.
出处
《营养学报》
CAS
CSCD
北大核心
2008年第5期508-511,共4页
Acta Nutrimenta Sinica
