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血清同型半胱氨酸及尿微量白蛋白与2型糖尿病肾病的相关性研究 被引量：7

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摘要 高同型半胱氨酸血症（Hyperhomocysteineroia，hHCY）与心脑血管病有密切联系。其升高程度与血管病变的严重性一致^[1]。糖尿病（DM）极易合并血管病变，而糖尿病肾病（DN）是糖尿病微血管病中常见而严重的并发症。本文探讨2型DN患者血清Hcy水平与尿微量白蛋白的关系，以期为DN患者的发病机制提供相关性提示。
作者 倪红辉
机构地区 江苏省苏北人民医院临床医学检测中心
出处 《实验与检验医学》 CAS 2008年第5期583-583,524,共2页 Experimental and Laboratory Medicine
关键词 2型糖尿病肾病 血清同型半胱氨酸 尿微量白蛋白 高同型半胱氨酸血症 血管病变 心脑血管病 微血管病 发病机制
分类号 R587.2 [医药卫生—内分泌] R714.246 [医药卫生—妇产科学]
  • 相关文献

参考文献9

  • 1汤佩麟.高半胱氨酸与动脉粥样硬化关系的研究进展[J].心血管病学进展,1997,18(2):95-97. 被引量：16
  • 2[2]J Graham IM,Daly LE,Refsum HM,et al.Plsama homocysteine as a risk factor vascular disease.The European Concerted Action Project[J].JAM.A,1997,39(22):1390.
  • 3周灵丽,卢纹凯.2型糖尿病患者血浆总同型半胱氨酸水平与大血管病变的关系[J].中国糖尿病杂志,2003,11(4):265-267. 被引量：52
  • 4[4]Ozmen B,Ozmen D,Turgan N,et al.Associaton between homocysteinemia and renal function in patients with type 2 diabetes mellitus[J].Ann Clin Lab Sci,2002,32:279～286.
  • 5[5]Hoogeveen EK,Kostense PJ,Jager A,et al.Serum homocysteine level and protein intake are related to risk of microalbuminuria:The Hoom study[J].Kidney Int,1998,54(1):203～209.
  • 6[6]Lanfredini M,Fiorina P,Peca MG,et al.Fasting and postmethionine load homocysteine values are correlated with microalbuminuria and contribute to worsening vascular damage in non-insulin-dependent diabetes mellitus patients[J].Metabolism,1998,47(8):915～921.
  • 7[7]Wall RT,Harlan JM,Harker LA,et al.Homoeysteine-induced endothelial cell injury in vivo:a model for the study of vascular injury[J].Thromb Res,1980,18(1-2):113～121.
  • 8智喜梅,梁奕铨,肖亦斌,廖瑛,廖志红,余斌杰.同型半胱氨酸与2型糖尿病合并早期肾病的关系[J].中国糖尿病杂志,2002,10(1):18-21. 被引量：54
  • 9[9]EmotoM,Kanda H,Shoji T,et al.Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes[J].Diabetes Care,2001,24(3):533～538.

二级参考文献11

  • 1[1]Hankey GJ, Eikeboom JW. Homocysteine and vascular disease Lancet,1999,354: 407-413.
  • 2[3]Stamler JS, Osborne JA, Jaraki O, et al. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J clin Invest,1993,91:308-313.
  • 3[4]Tsai JC, Parrella MA, Yoshizumi M, et al. Promotion of vascular smooth muscle cell growth by homocysteine,a link to atherosclerosis. Proc Natl Acad Sci USA,1994,91:6369-6373.
  • 4[5]Harker LA, Slichter SJ, Scott CR, et al. Homocystinemia vascular injury and arterial thrombosis. N Engl J Med, 1974, 291:537-543.
  • 5[6]Rodgers GM, Conn MT. Homocysteine and atherogenic stimulus,reduces protein C activation by arterial and venous endothelial cells. Blood, 1990,75:895-901.
  • 6[7]Blom HJ, Kleinveld HA, Boers GH, et al. Lipid peroxidation and susceptibility of low-density lipoprotein to in vitro oxidation in hyperhomocysteinaemia. Eur J Clin Invest, 1995,2:149-154.
  • 7[8]Wollesen F, Brattstrom L, Refsum H, et al. Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus. Kidney Int,1999,55:1028-1035.
  • 8[9]Mazza A, Giugliano D, Motti C, et al. Glycemia,MTHFR genotype and low homocysteine in uncomplicated type 2 diabetic patients. Atherosclerosis, 2000,149:223-224.
  • 9[10]Chico A, Pereza A, Cordoba A, et al.Plasma homocysteine is related to albumin excretion rate in patients with diabetes mellitus:a new link between diabetic nephropathy and cardiovascular disease?Diabetologia,1998,41:684-693.
  • 10廖瑛,梁奕铨,智喜梅,廖志红.高效液相色谱荧光检测法测定血浆中总同型半胱氨酸[J].色谱,2000,18(1):49-51. 被引量：21

共引文献113

同被引文献81

引证文献7

二级引证文献30

实验与检验医学
2008年 第5期

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