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IGF-Ⅰ基因的一个多态性与食管鳞状细胞癌的关联研究

Association Study Between a Polymorphism in the IGF-Ⅰ Gene and Esophageal Squamous Cell Carcinoma
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摘要 目的:检测类胰岛素生长因子1(IGF-Ⅰ)基因微卫星多态性CA重复与食管鳞状细胞癌是否关联。方法:应用荧光标记片段分析法对78例食管鳞状细胞癌患者和470例正常对照进行基因分型,并用非条件性Logistic回归分析微卫星多态性与食管鳞状细胞癌的关联性。结果:IGF-Ⅰ基因微卫星多态性CA重复与食管鳞状细胞癌的发病没有关联。结论:IGF-Ⅰ基因微卫星多态性CA重复在食管鳞状细胞癌的发病过程中不起主要作用。 Objective： To investigate the relationship between a microsatellite polymorphism （CA repeats） in the insulin - like growth factor Ⅰ gene and the risk of esophageal squamous cell carcinoma. Methods ： IGF - Ⅰ microsatellite polymorphism was genotyped among 78 cases with esophageal squamous cell carcinoma and 470 normal eontrots by fluorescent labeled fragment anal- ysis. And data were analyzed using unconditional logistic regression to evaluate the association of examined polymorphism with esophageal squamous cell carcinoma. Results： No association was found between IGF - Ⅰ microsatellite polymorphism and esophageal squamous cell careinoma. Conclusion： IGF- Ⅰ mierosatellite polymorphism （CA repeats ） does not play a major role in the development of esophageal squamous cell carcinoma.
作者 贾彦彬 张建祖 闫艳
机构地区 包头医学院病原生物教研室 包头医学院第一附属医院
出处 《包头医学院学报》 CAS 2008年第5期452-453,486,共3页 Journal of Baotou Medical College
关键词 食管鳞状细胞癌 类胰岛素生长因子1 微卫星多态性 Esophageal squamous cell carcinoma Insulin - like growth factor Ⅰ （ IGF - Ⅰ ） Microsatillite polymorphisrn
分类号 R735.1 [医药卫生—肿瘤] R737.25 [医药卫生—肿瘤]
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参考文献14

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包头医学院学报
2008年 第5期

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