摘要
目的探讨纳洛酮辅助治疗重症酒精戒断综合征（AWS）的方法。方法将50例AWS患者随机分为治疗组和对照组各25例，均给予对症支持治疗。治疗组在综合对症治疗的基础上静脉加用纳洛酮，每次0．8～1．6mg，每隔8h静脉给0．8mg维持，谵妄、震颤、癫痫、幻觉、高热等症状控制后停用。观察两组震颤性谵妄、癫痈、幻觉、高热等重症综合征被控制的时间，记录两组镇静药物使用剂量，评定疗效并观察药物不良反应。结果治疗组重症综合征消失时间、地西泮总使用量、氟哌啶醇总使用量分别为（58±24．7）h、（900．00±222．81）mg和（735．33±121．28）mg，对照组分别为（98．5±36．7）h，（1332．8±241．0）mg和（1727．33±188．01）mg，治疗组各指标均小于对照组（均P〈0．01）。治疗组镇静药用量、呼吸道分泌物和呼吸抑制发生率均低于对照组，未见明显不良反应，且可改善疾病预后。结论纳洛酮辅助救治重症酒精戒断综合征可明显缩短病程、提高疗效且安全可靠。
Objective To evaluate the effectiveness and safety of naloxone combined with conservative therapy in the treatment of severe alcohol withdrawal syndrome. Methods 50 patients with alcohol withdrawal syndrome were randomly assigned to naloxone group and control group. Each group has 25 patients. The control group received comprehensive conservative therapy. Naloxone group was given with a combination of naloxone with conservative therapy. The alleviation of symptoms and side effects were monitored. Results The duration of symptoms was shorter in naloxone group versus the control group with a statistical significance （ P 〈 0. 01 ） , and combination with naloxone reduced the dosage required for benzodiazepines and haloperidol（P 〈 0.01 ）. The combined therapy with naloxone decreased the need of sedatives, which may lead to hypersecretion of respiratory mucous. Moreover, there were no noticeable side effects. The prognosis was improved obviously, as well. Conclusion The combination of conservative therapy with naloxone is an effective and safety treatment for alcohol withdrawal syndrome.
出处
《医药导报》
CAS
2008年第11期1340-1342,共3页
Herald of Medicine
关键词
纳洛酮
酒精戒断综合征
重症
Naloxonee
Alcohol withdrawal syndrome,Sever
