摘要
蛋白质组学的研究由二维电泳的引进揭开序幕,而近年来质谱技术和蛋白质芯片的广泛引入使得蛋白质组学技术得到越来越多的应用,尤其是应用在肿瘤研究中。癌蛋白质组学以整个肿瘤特异性蛋白信号网络为靶标,已应用到多种癌症的研究中,成为肿瘤研究的重要工具。本文将对癌蛋白质组学技术原理以及近年来在肿瘤研究中的应用加以综述。
Proteomic research first came to the fore with the introduction of two-dimensional gel electrophoresis and proteomics has been increasingly applied to cancer research with the wide-spread introduction of mass spectrometry and protein chip. As important research tools, oncoproteomics that targets the entire cancer-specific protein network has already been applied in cancer research. In this article the development of the oncoproteomics and its applying in cancer is reviewed.
出处
《基础医学与临床》
CSCD
北大核心
2008年第10期1107-1110,共4页
Basic and Clinical Medicine
基金
国家高技术研究发展计划(863计划2007AA021010)
教育部留学归国科研基金
关键词
癌蛋白质组学
二维电泳
质谱技术
蛋白质芯片
oncoproteomics
two dimensional
electrophoresis mass spectrometry
protein chip
