摘要
糖基化作用是最重要的翻译后修饰之一。多种多样的半乳糖化反应使得生物体可以表达极其多样的寡糖结构。α1,3-半乳糖转移酶(GGTA1)、ABO血型抗原合成酶及异红细胞糖苷酯合成酶(iGb3 s)均催化半乳糖在α1,3糖苷键之间的转移。前两者合成的抗原在异种移植(Galα1,3-Gal抗原,简称αGal)和同种异基因移植(ABO抗原)的免疫排斥反应中发挥重要的作用。本综述主要讨论这些转移酶的特性、其合成的抗原及其在移植中的意义。
Glycosylation is one of the most important post-translational modifications. The variety of galactosylation reactions significantly contributes to the tremendous diversity of oligosaccharide structures expressed by living organisms, α1, 3 galactosyltransferase （GGTA1）, ABO blood group antigens synthetase and isogloboside 3 （iGb3）synthase catalyze the transfer of galactose via α1,3 linkages. Both ABO （for allo） and ,α-galactose（αGal） （for xeno）antigens expressed in the donor tissue produce a marked effect on immunological rejection of transplantation. In this review,the features of these enzymes, the antigens they synthesize and the function they perform during transplantation are discussed.
出处
《军事医学科学院院刊》
CSCD
北大核心
2008年第5期478-481,共4页
Bulletin of the Academy of Military Medical Sciences
