摘要
目的探讨青年人血清尿酸水平与冠心病的关系。方法2005年1月至2008年4月在北京大学第一医院接受冠状动脉造影检查的年龄≤45岁的住院患者共156例。按照造影结果,分为冠心病组（96例）和对照组（60例）。冠心病组又分为单支病变亚组（55例）、双支病变亚组（21例）和三支病变亚组（20例）。分析血清尿酸水平与冠心病及冠状动脉病变严重程度的关系。结果冠心病组血清尿酸水平显著高于对照组（347.3±77.8 mmol/L比306.1±76.6 mmol/L,P〈0.01）,并且随着冠状动脉受累支数的增多,血清尿酸水平逐渐增高（单支病变亚组322.8±74.6 mmol/L,双支病变亚组373.8±59.3 mmol/L,三支病变亚组383.6±82.1 mmol/L,P〈0.01）。经Cumulative Logit模型分析,在调整了其他危险因素后,血清尿酸水平仍与冠状动脉病变支数独立相关（OR=1.008,95%CI：1.003-1.013,P〈0.01）。结论在本组青年人群中,血清尿酸水平升高与冠心病及冠心病的严重程度具有显著相关性,而且在青年人群中,血清尿酸水平升高是冠心病发病的独立危险因素。
Objective To investigate the relationship of serum uric acid level to the risk of coronary artery disease in young adults. Methods One hundred and fifty six young adults （ ≤45 years） hospitalized in Peking University First Hosipital during January 2005 to April 2008 were divided into coronary heart disease （CHD） group （96 cases） and control group （60 cases）, according to coronary angiography. The CHD group was then sub-divided into 3 groups： single-vessel group （n =55） , double-vessel group （n =21 ） and multi-vessel group （n = 20）. The relationship of serum uric acid level to the risk of CHD was analyzed. Results The serum uric acid level in CHD group was higher than that in control group （347.3 ± 77.8 μmol/L vs 306. 1 ±76. 6 μmol/L, P 〈0.01 ）. Moreover, the serum uric acid level was associated with the severity of CHD （ single-vessel group：322. 8 ± 74.6 μmol/L, double-vessel group：373.8 ± 59. 3 μmol/L, multi-vessel group：383.6 ±82. 1 μmol/L, P 〈0. 01 ）. Cumulative Logic model analysis revealed that serum uric acid level was indepedently associated with the severity of CHD （ OR = 1. 008, 95% CI： 1. 003 - 1. 013, P 〈 0.01 ） after adjusting for other risk factors. Conclusion Increased level of serum uric acid was an independent risk factor of CHD in adults younger than 45 years old.
出处
《中国介入心脏病学杂志》
2008年第5期277-279,共3页
Chinese Journal of Interventional Cardiology
关键词
青少年
冠状动脉疾病
尿酸
Adolescent
Coronary disease
Uric acid
