摘要
目的:观察藿胆丸对鼻炎-鼻窦炎的抗炎作用,探讨藿胆丸的作用机理,为临床应用提供科学依据。方法:采用血清药理学方法研究藿胆丸含药血清对鼻炎相关细菌金黄色葡萄球菌、肺炎链球菌、大肠杆菌和肺炎克雷伯菌的体外抑菌效应;采用小鼠鼻炎模型研究藿胆丸对局部炎症组织中炎症化学介质组胺和前列腺素的影响。结果:藿胆丸含药血清对鼻炎相关细菌金黄色葡萄球菌、肺炎链球菌、大肠杆菌、肺炎克雷伯菌无显著影响;藿胆丸高、中剂量组能明显降低小鼠组胺荧光值和前列腺素OD值。结论:藿胆丸治疗急慢性鼻炎-鼻窦炎的作用可能并非通过抑制相关细菌实现;藿胆丸通过抑制炎症发生、发展过程中炎症组织中组胺、前列腺素的含量发挥抗炎作用。
Objective：The Anti-inflammatory function of Huo-dan Pill on Rhinitis-nasosinusitis was studied to provide scientific evidence for clinical application. Methods：Serum pharmacology was used to studied anti-bacteria effect of different time drug-containing serum of Huo-Dan Pill on Staphylococcus aureus,Streptococcus pneumoniae, Bacillus coli and Klebsiellar pneumonia. Rhinitis model of mice was applied to study the effect of Huo-Dan Pill on HA and PGE. Results： Different time drug-containing serum of 21.6 g/kg Huo-Dan Pill had no obviously effects on Staphylococcus aureus, Streptococcus pneumouiae,Bacillus coli and Klebsiellar pneumonia. 6.24 g/kg and 3.12 g/kg Huo-Dan Pill remarkably decreased HA and PGE contained in inflammatory tissue of rhinitis model mice. Conclusion ： Therapeutic effect of Huo-Dan Pill on rhinitis-nasosinusitis may be attributed to the decreasing effects of HA and PGE contained in inflammatory tissue but not due to its inhibition of related bacteria.
出处
《世界中西医结合杂志》
2008年第5期257-259,共3页
World Journal of Integrated Traditional and Western Medicine
关键词
藿胆丸
鼻炎-鼻窦炎
抗炎
Huo-dan Pill
rhinitis-nasosinusitis
anti-inflammatory
