摘要
目的探索一种适用于研究糖尿病对口腔疾病影响的理想动物模型的建立方法。方法50只Wistar大鼠随机分为实验组(n=40)与对照组(n=10)。实验组静脉注射30mg/kg的链脲佐菌素(STZ),每周一次连续4周建模,观察血糖、尿糖及组织学损害。结果实验组大鼠产生明显迟发性胰岛损害,尿糖阳性,血糖与对照组有明显差别(P<0.05),组织学表现为自身免疫性胰岛炎特征。结论STZ小剂量多次静脉注射诱导大鼠糖尿病(DM)动物模型适用于糖尿病以及糖尿病相关口腔疾病的研究。
Objective To explore an ideal establishment method of the diabetic animal model for studying the influence of diabetes mellitus on oral diseases. Methods Fifty Wistar rats were randomly divided into two groups：experimental group（ n = 40）and control group（ n = 10）. Forty Wistar rats in experimental group were intravenously injected with streptozotocin（STZ）of 30 mg/kg once a week for four weeks to establish the diabetic model. The changes of blood sugar, urine sugar and histological damage were observed. Results The histological changes showed the delayed islet damage and autoimmune islet inflammation in experimental group. The urine sugar and blood sugar were significantly higher in experimental group than in control group（ P 〈0. 05）. Conclusion Diabetes mellitus（DM）animal model induced by intravenously injecting multiple low-dose of SWZ can be used for studying oral diseases in patieats with diabetes and diabetes-related diseases.
出处
《山西医科大学学报》
CAS
2008年第10期879-881,共3页
Journal of Shanxi Medical University
关键词
糖尿病
动物模型
链脲佐菌素
diabetes mellitus
animal model
streptozotocin
