摘要
[目的]探讨益气活血散结法对肺纤维化的干预效果及机制。[方法]通过临床与动物实验系统研究益气活血散结法为主要治则的中药复方对肺纤维化的干预效果及机制。[结果]益气活血散结法不仅能明显改善肺纤维化患者的临床症状,提高生活质量,而且能抑制肺泡炎症,减少肺组织损伤,显著降低转化生长因子-β1(TGF-β1)的过度表达。[结论]益气活血散结法能改善肺纤维化患者临床症状,对防治肺纤维化有一定的作用。
[Objective] To explore the intervention effect of tonifying Qi, activating blood and dispersing accumulation method on pulmonary fibrosis and analyze its mechanism. [Methods] A systematic clinical observation and animal experimental study on the effect of tonifying Qi, ac- tivating blood and dispersing accumulation on pulmonary fibrosis and their mechanism research were carried out. [Results] The method of tonifying Qi, activating blood and dispersing accumulation could not only improve the patients＇ symptoms obviously, but also inhibit the inflammation in lung alveoli, reduce TGF-β1 over-expression. [Conclusion] The method of tonifying Qi, activating blood and dispersing accumulation can improve the patients＇ symptoms, and play an important role in preventing and curing pulmonary fibrosis.
出处
《天津中医药大学学报》
CAS
2008年第3期209-212,共4页
Journal of Tianjin University of Traditional Chinese Medicine
关键词
肺纤维化
益气活血散结法
转化生长因子-Β1
pulmonary fibrosis
the method of tonifying Qi, activating blood and dispersing accumulation
TGF-β1
