摘要
目的研究天然有效成分茶多酚对鼻咽癌HNE-1及HNE-1(200)细胞株增殖的抑制作用。方法本研究以鼻咽癌HNE-1细胞株和HNE-1(200)耐药细胞株为研究对象,采用MTT法测定茶多酚对两组细胞的增殖抑制率。结果茶多酚对两组实验细胞均有抑制作用,且这种作用呈浓度依赖关系;茶多酚对两种细胞株的抑制率没有显著差别。结论茶多酚对鼻咽癌耐药细胞株和非耐药细胞株均有相似而明显的增殖抑制作用,这为茶多酚的进一步研究和应用打下了基础。
Objective To investgate the effects of tea polyphenols on inhibiting cell proliferation of the HNE-1 cell line and HNE-1（200） subline. Methods NPC HNE-1 cell line and HNE-1 （200）subline were ehosed to carry out the study. By means of MTT,tea polyphenols was used to detect the rate of inhibition in of the cell proliferation. Results Tea polyphenols had the effect on the inhibition of cell proliferation in both cell lines, the effect depended on the concentration of tea polyphenols. There were no significant differences between the two cell lines. Conclusion Tea polyphenols has the similar effect on the inhibition of cell proliferation in both the HNE-1 cell line and the HNE-1 （200）multidrug resistance subline. Thus the laboratroy evidence for the use of tea polyphenols as an adjunct to chemical therapy is provided.
出处
《重庆医学》
CAS
CSCD
2008年第20期2266-2267,共2页
Chongqing medicine
基金
重庆市卫生局中医处资助课题〔渝中医(2006)27号2006-B-16〕
