摘要
目的：探讨膀胱移行细胞癌癌基因蛋白表达与预后的关系。方法：应用免疫组织化学，检测１５０例膀胱移行细胞癌ｐ２１、ｐ１８５、ｐ５３三种蛋白表达。结果：膀胱移行细胞癌ｐ２１、ｐ１８５、ｐ５３蛋白表达阳性率分别为５９．３％、５５．３％、２９％。其中７３例膀胱移行细胞癌存在两种以上蛋白共同表达。ｐ２１、ｐ１８５蛋白表达阳性率与膀胱移行细胞癌分级呈负相关（Ｐ＜０．０５），ｐ５３蛋白表达阳性率与膀胱移行细胞癌分级呈正相关（Ｐ＜０．０１）。ｐ２１蛋白表达阳性率与预后呈负相关，ｐ５３与预后呈正相关。结论：ｐ２１、ｐ５３蛋白表达检测有助于判断膀胱癌的预后。
Objective: To explore the relationship between the expression of the oncogenes of transitional cell carcinoma of the bladder and its prognosis. Methods: The expression of p21, p185 and p53 proteins in 150 cases of transitional cell carcinoma of the bladder was determined with immunohistochemistry. Results: The positive rates of expression for p21, p185 and p53 proteins were 59.3%, 55.3% and 29% respectively. Expression of more than two kinds of oncogenes was seen in 73 cases. The positive rates of expression for p21 and p185 proteins were negatively correlated to the pathological grade (P<0.05) while that for p53 protein was positively correlated to the pathological grade (P<0.01). The positive rate of expression for p21 protein was negatively while that for p53 protein positively correlated to the prognosis of the transitional cell carcinoma of the bladder. Conclusion: Determination of the expression of p21 and p53 proteins is helpful for predicting the prognosis of carcinoma of the bladder.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1997年第6期534-536,共3页
Journal of Third Military Medical University
