摘要
目的：探讨高龄初产妊高征孕妇体内过氧化反应。方法：测定正常初产妇、妊高征孕妇妊娠晚期母血过氧化脂质（LPO）、超氧化物歧化酶（DOD）的含量。结果：1．高龄初产妇母血LPO较非高龄初产妇明显升高，SOD明显下降，P＜0．05。孕妇年龄与母血LPO呈明显正相关，与SOD呈明显负相关，P均＜0．05。2．妊高征孕妇LPO较正常孕妇显著增高，SOD显著下降，P＜0．05，并随病情加重LPO水平升高、SOD水平下降更为显著，P＜0．05。3．高龄初产妊高征孕妇母血LPO含量较非高龄初产妊高征孕妇明显增高，P＜0．05，而SOD则无显著变化，P＞0．05。4.妊高征孕妇胎儿宫内生长发育迟缓（IUGR）发生率较正常孕妇显著升高，P＜0．025，各组脐血清LPO、SOD含量无显著差异，P＜0．05。结论：高龄初产妊高征孕妇体内过氧化作用明显增强，LPO水平的升高可能为高龄初产妇妊高征发生率及IUGR发生率增加的原因之一。
To investigate peroxidation in elderly primipara with pregnancy induced hypertension (PIH). The con-tent of serum levels of lipid peroxides (LPO) and superoxide dismutase (SOD) in normal primipara and primipara with PIH in third trimester were determined. The serum levels of LPO was higher and SOD was lower in elderly primipara than that of younger primipara (P＜0. 05)。 Maternal age and serum levels of LPO had obviously positive relationship, P ＜0. 05, but SOD had obviously negative relationship, P＜0. 05. The serum levels of LPO was higher and SOD was lower in pregnant women with PIH than that of normal pregnant women, P＜0. 05, and the differences became more obvious with the deteriorating of the disease. The serum levels of LPO in elderly primipara with PIH was higher than that of younger primipara with PIH, P＜0.05, but the serum levels of SOD in two groups had not obviously difference,＜0. 05, the incidence of IUGR in pregnant women with PIH was higher than that of normal pregnant women, ,P<0. 025. The difference of umbilical blood LPO and SOD between the four groups were not significant, P>0. 05. Perox-idetion in elderly primipara with PIH are obviously increased. The occurrence of PIH and IUGR are associated with the high level of maternal serum. LPO.
出处
《上海医学》
CAS
CSCD
北大核心
1997年第12期691-693,共3页
Shanghai Medical Journal
基金
1994年度高等院校博士学科点基金
关键词
高龄初产妇
脂质过氧化
妊娠高血压
综合征
Elderly primipara Pregnancy induced hypertension Lipid peroxides Superoxide dismutase
