摘要
为探讨腹腔内化疗后腹腔粘连形成机理及其针对性预防措施。采用^(125)I-纤维蛋白原作为示踪标记物，放射免疫分析法比较了卡铂液或合有透明质酸钠、人体白蛋白的卡铂复合液腹腔内化疗后，腹腔内纤维蛋白原渗出量和腹膜表面纤维蛋白沉积量变化。结果：卡铂液腹腔内灌注可明显地增加腹腔内纤维蛋白原的渗出和腹腔表面纤维蛋白的沉积，卡铂液中卡铂浓度与腹腔内纤维蛋白原渗出和腹膜表面纤维蛋白的沉积量呈显著正相关。而卡铂复合液组腹腔内纤维蛋白原渗出量和纤维蛋白沉积量明显低于卡铂液组，与对照组接近。本文结果表明：卡铂复合液对腹腔内化疗中腹腔内纤维蛋白原渗出和纤维蛋白沉积量有明显的抑制作用，对抑制由于反复腹腔内化疗而引起的腹腔粘连有重要作用。
The present study is designed to investigate the mechanism of the intraabdominal adhesion formation af-ter intraperitoneal chemotherapy with carboplatin and to get an effective prevention method. 125I-labeled fibrinogen(125I-F) was used as a tracer, the inflow of fibrinogen into peritoneal cavities, and influx and accumulation of fibrinogen/fib-rin in the peritoneal lining tissues were measured using radioimmunoassay after intraperitoneal chemotherapy with the carboplatin liquid or the carboplatin mixture liquid. The percentage of circulating125I-F extravasated into the peritonealcavity was increased significantly in rats treated with carboplatin liqiud as compared with the control group. Accumula-tion of the125I-F in peritoneal lining tissues was also increased above control levels. However, in rats treated with carbo-platin mixture liqiud, the percentage of circulating125I-F that extravasated into the Peritoneal cavity and the accumulationof the FN in peritoneal1 lining tissues were decreased significantly. It is suggested that intraperitoneal chemotherapy withcarboplatin mixture liquid may inhibite the over increased fibrinogen influx and fibrin accumulation in peritoneal cavity,and therefore inhibite the intraabdominal adhesion formation. The liquid is a more suitable nuid for the intraperitonealchemotherapy of malignant tumour.
出处
《上海医学》
CAS
CSCD
北大核心
1997年第12期685-687,共3页
Shanghai Medical Journal
关键词
卡铂
纤维蛋白原
肿瘤
药物疗法
Intraperitoneal chemotherapy Carboplatin Fibrinogen Intraabdominal adhesion
