摘要
观察38例慢性充血性心力衰竭（CHF）患者和25例正常人血胰岛素水平及胰岛素敏感性指数（IAI）的变化，以探讨胰岛素抵抗（IR）在CHF的作用。结果显示：CHF患者的空腹血糖、空腹血胰岛素（FIS）、IAI明显高于对照组（均P＜0．01），不同心功能分级组间IAI差异显著（P＜0．05～0．01）。提示：①CHF患者存在IR和高胰岛素血症（HIS）已与心衰程度有关；②IR和HIS可能是CHF继发性病理生理变化，并可能对CHF发展演变及临床处理产生一定影响。
The aim of this study was to investigate the existance of abnormalities of insulin sensitivity in patients with congestive heart failure (CHF). Plasma glucose level and insulin concentration were measured in 38 patients with CHF and in 25 control subjects. The results showed that the heart failure group had a significantly greater mean fasting plasma glucose level and insulin concentration (P<0. 01) respectively, and a markedly higher insulin sensitivity index than that of control group (P<0. 01). It can be suggested that patients with CHF exist,hyper-insulinaemia and insulin resistance. Insulin resistance and hyper-insulineamia complicated in patients with CHF may contribute to the progressive deterioration in myocardial function and its clinical features.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1997年第6期334-336,共3页
Journal of Clinical Cardiology
关键词
充血性心力衰竭
胰岛素抵抗
病理
Congestive heart failure Insulin resistance Hyperinsulinaemia
