1Boisclair MD,Lane DA ,Philippou H, et al. Thrombin Prodnetion, inactivation and expression during open heart surgerymeasured by assays for activation fragments including a new ELISA for prothrombin Fragment F 1+2 [J]. Thromb Haemost, 1993,70 :253- 258.
2Brister SJ ,Ofosu FA ,Buchanan MR. Thrombin generation during cardiac surgery:is heparin the ideal anticoagulant [J]? Thromb Haemost, 1998,70 (2):259-262.
3Stone Sr,Hofsteenge J. Kinetics of the inhibtion of thrombin byhirudin[J]. Biochem, 1986,25 : 4622-6628.
4Talbot M. Biology of recombinant hirudin (CGP39393):a new prospoc in the treatment of thrombosis som[J]. Thromb Hoemost, 1989,15:293-301.
5Marki WF,Wallis RB. The anticoagulant and antithrombotic properties of hirudins [J]. Thromb Haemost, 1990,61 : 344-348.
6Wachtforgel Y,Kucich U, Hack CE,et al. Aprotinin inhibits the contact, neutrophil,andplatelet activation systems during simulated cxtacorporal perfu-gion [J]. Jthorac Cardiovaase Surg, 1993, 106:1-10.
7Zoldhelyi P, Webater MWI, Fucter V, et al. Recombinant hinudin in palieuls will chronic stablc coronary artery dicaese[J]. Circulation, 1993,88:2015-2022.
8Lindhout T,Blezer R,Hemker HC. The anticoagulant mechanism of action of recombinant hirudin (CGP 39393) in plasma [J]. Thromb Haemost, 1990,64 : 464-468.
9Walenga JM,Bakhos M, Messmore HL,et al. Potential use of recombinant hirudin as an anticoagulant in a car diopulmation bypass model[J]. Ann Thorac Surg,1991,51:271-277.
10Olson ST,Bjork I. Predominant contibution of surface approximarion to thrombin reaction[J]. J Biol Chem, 1991,266 : 6353- 6362.
4WHITAKER I S,IZADI D.OLIVER D W,et al.Hirudo Medicinalis and the plastic surgeon[J].Br J Plastic Surg,2004,57(4):349.
5LENSING A W,PRANDONI P,H PRINS M,et al.Deep-vein thrombosis[J].Lancet,1999,353(9151):479-485.
6ERIKSSON B I,EKMAN S,KALEBO P,et al.Prevention of deep vein thrombosis after total hip replacement:direct thrombin inhibition with recombinant hirudin,CGP 39393[J].Lancet,1996,347(9002):635-639.
7ERIKSSON B I.New therapeutic options in deep vein thrombosis porphylaxis[J].Semin Hematol,2000,37(3 suppl 5):7-9.
8ERIKSSON B I,WILLE-JORGENSEN P,et al.Successful treatment of heparin-induced thrombocytopenia(HIT)typeⅡ in childhood with recombinant hirudin[J].Monatsschr Kinderheikd,1997,145:606-612.
9LOUIS P.Bucky,Leeches latch on after reconstructive surgery[J].Journal of the National Cancer Institute,1999,91(20):1715.
10COTTLER PS,GAMPPERTJ,RODEHEAVERGT,et al.Evaluation of clinically applicable exsanguination treatments to alleviate venous congestion in an animal akin flap model[J].Wound Repair Regen,1999,7:187.
