摘要
按ＷＨＯ多国家血管研究方案，对１９９３年患病率调查所筛选出来的２型糖尿病患者的血管病变进行了前瞻性的调查分析。ＤＭ９６６例和正常糖耐量２９９６０例（均经７５ｇＯＧＴＴ诊断）。并发症判定标准：①高血压（ＨＴ）：收缩压（ＳＢＰ）≥２１．３ｋＰａ（１６０ｍｍＨｇ）或舒张压（ＤＢＰ）≥１２ｋＰａ（９０ｍｍＨｇ）；②冠心病（ＣＨＤ）：临床症状及明尼苏达编码的心电图诊断；③微量白蛋白尿（ＭＡＵ）：尿白蛋白排出量（ＵＡＥ）２０～２００μｇ／ｍｉｎ；④脑血管病（ＣＶＤ）：采用问卷和查体调查，有阳性征象者行ＣＴ证实；⑤糖尿病视网膜病变（ＤＲ）为散瞳检查或眼底荧光造影确定。结果显示：初诊２型糖尿病患者ＨＴ、ＣＨＤ、ＣＩ和ＭＡＵ的患病率分别为３７．３７％，９．３２％，５．５３％和２１．０５％均显著地高于对照组的相应患病率（１４．４％，２．４６％，１．１９％和４．３２％）。ＤＲ的患病率为１６．６％，对照组未进行荧光造影。经多元逐步回归分析，ＦＢＳ、ＭＢＰ和ＢＭＩ升高以及血脂紊乱为其血管并发症的独立危险因素。上述并发症的患病率显著高于对照组。控制血糖和血压、保持理想体重、纠正脂质代谢紊乱等。
This was a prospective study to determine the prevalence of vascular complications and its related risk factors in newly diagnosed type 2 diabetes mellitus patients. There were altogether 966 type 2 diabetes mellituspatientsand29960controlsubjectswithnormal glucose tolerance, aged between 30 and 64 years and screened from the Shougang Corporation within the Beijing area. According to WHO protocol and criteria, the complications were diagnosed. The results showed that the prevalence of hypertension (HT) (37.37%), coronaryheartdisease(CHD) (9.32%), cerebralinfarction (CI 5.53%), and microalbuminuria (MAU) (21.05%) were statistically higher than those in the controls, HT(14.4%), CHD(2.46%), CI(1.19%), and MAU(4.32%) respectively. Prevalence of diabetic retinopathy (DR) was 16.6% in type 2 diabetes mellitus patients. However, there was no difference in prevalence of cerebral hemorrhage between DM patients and non_DM subjects. The logistic regression analysis indicated that the statistically significant risk factors for CHD andMAUwereincreaseinBMI, MBP, FBS (or HbA1c) anddropof HDL_C. The prevalence of vascular complications was much higher in type 2 diabetes mellitus patients than in normal controls. The risk factors suchas hypertension, obesity, dyslipidemia and poorly controlled diabetes were found in the patients with diabetic complications. The results suggest that early diagnosis and correction of these abnormalities are crucial to prevent chronic diabetic complications.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1997年第4期201-205,共5页
Chinese Journal of Endocrinology and Metabolism
基金
全军"八五"科研课题经费资助
关键词
糖尿病
并发症
血管疾病
患病率
Type 2 diabetes mellitus Vascular complications
