摘要
为探讨甲钴胺对糖尿病神经病变的疗效，来自上海６家医院的１２４例糖尿病神经病变患者以甲钴胺治疗（前４周５００μｇ，肌肉注射每周２次；后８周５００μｇ，每天３次，口服）。结果：注射４周后症状和体征即改善，口服８周后改善更加明显；改善率分别为９０．６％（下肢自发痛）、８６．９％（上肢自发痛）、９４．５％（感觉减退）、８９．８％（麻木）；在治疗４周后，运动和感觉神经传导速度即已明显提高，并维持至１２周；振动觉阈值在治疗４周后虽无明显变化，但在１２周时明显下降；心脏自主神经功能测试在治疗４周和１２周时皆无明显改善；仅有７例出现轻微副作用，但无一例因副作用退出研究。提示甲钴胺是治疗糖尿病神经病变的一种安全。
124 patients with diabetic neuropathy (DN) from 6 hospitals in Shanghai were given Methy_lcobalamin (500μg, i.m., 2 times per week for 4 weeks; then 500μg, tid, per oral, for another 8 weeks). The results showed that the improvement of symptoms and signs of neuropathy began to appear after intramuscular injection for 4 weeks, and more obvious improvement was observed after oral therapy for another 8 weeks. The efficacyrateswere90.6% for spontaneous pain in lower limbs, 86.9% for spontaneous pain in upper limbs, 94.5% for hypoesthesia and 89.8% for numbness after 12 weeks of treatment. The significant increase in motor and sensory nerve conduction velocity was observed at 4th week, and maintained till 12th week. There was no change in detection threshold of vibration at 4th week, but obvious decrease was detected at 12th week.There wasnomarkedchangeincardiac autonomic nerve function both at 4th week and 12th week. Only 7 cases (5.6%) experienced mild side reactions for which none withdrew from this study. These results imply that methylcobalamin is an effective and safe drug for diabetic neuroparthy.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1997年第4期197-200,共4页
Chinese Journal of Endocrinology and Metabolism
